Table 2 K-means clustering of down-regulated genes (Set 4).
Putative Id | Uniprot Accession | Score | Description | Fold change (6, 24, 72, 120 h) |
|---|---|---|---|---|
Set 4 (54 genes): Delayed and persistent down-regulation | ||||
Peroxisome proliferator-activated receptor-binding protein | Q15648 | 7E-25 | Transcription | -1.08, -1.64, 1.03, -1.28 |
RNA polymerase B transcription factor 3 | P20290 | 2E-71 | Transcription | -1.22, 1.18, 1.01, -2.17 |
Thioredoxin-binding protein 2 | Q9H3 M7 | 3E-22 | Transcriptional repression | -1.17, -1.85, -1.21, -1.08 |
Probable ATP-dependent RNA helicase DDX48 | Q91VC3 | 1E-140 | RNA splicing | -1.16, 1.13, 1.15, -2.17 |
Cleavage and polyadenylation specificity factor 5 | Q7T3C6 | 1E-125 | mRNA processing | -1.21, 1.42, -1.05, -2.56 |
40S ribosomal protein S25 | Q6Q311 | 5E-30 | Translation | -1.14, 1.01, 1.13, -2.63 |
Translation initiation factor eIF-2B subunit gamma | Q4R6T3 | 8E-6 | Translation | -1.03, -3.85, -2.78, -1.51 |
Phospholipase A2 | P00592 | 1E-31 | Signal transduction | 1.09, -1.24, -1.45, -3.03 |
Phospholipase D | O17405 | 4E-27 | Signal transduction | 1.04, -1.37, -1.21, 1.24 |
Calcium/calmodulin-dependent protein kinase type II δ chain | Q13557 | 2E-70 | Signal transduction/regulation of cell growth | -1.21, -1.77, -1.82, -1.24 |
Proto-oncogene tyrosine-protein kinase receptor ret | P35546 | 1E-25 | Signal transduction/development | -1.10, -1.11, -1.21, -1.92 |
Translationally-controlled tumor protein | Q9DGK4 | 2E-57 | Apoptosis, negative regulator | -1.43, 1.16, 1.08, -2.78 |
Trypsin | P35034 | 2E-37 | Proteolysis/digestion | -1.12, -1.06, -1.15, -2.94 |
Elastase-1 | Q7SIG3 | 1E-112 | Proteolysis/pancreas | -1.21, -1.49, -1.47, -2.17 |
α-1-antitrypsin-like protein CM55-MS | O54758 | 3E-69 | Protease inhibitor/extracellular | -1.13, -1.25, -1.52, -1.01 |
Nucleolar GTP-binding protein 1 | Q9BZE4 | 4E-41 | Negative regulation of protein ubiquitination | -1.01, 1.16, -1.05, -3.57 |
Rotamase 1B | P68106 | 2E-52 | Protein folding/cytoplasm | 1.42, -2.63, -2.17, -1.27 |
Signal sequence receptor subunit α | P45433 | 1E-101 | Protein folding/ER | -1.27, 1.87, 1.01, -3.03 |
Adenylosuccinate synthetase isozyme 2 | P46664 | 8E-16 | Nucleotide biosynthesis | -1.03, -1.64, -1.57, -1.64 |
Nicotinamide riboside kinase 2 | Q9NPI5 | 1E-73 | Nucleotide biosynthesis | -1.30, 1.03, 1.03, -2.78 |
Liver-specific uridine phosphorylase | Q8CGR7 | 1E-84 | Nucleotide catabolism | 1.51, -1.09, -1.72, 2.22 |
Malonate-semialdehyde dehydrogenase [acylating] | Q07536 | 1E-131 | Valine & pyrimidine metabolism | -1.09, -1.04, -1.45, 1.14 |
Urate oxidase | P11645 | 1E-111 | Purine metabolism | -1.08, -1.47, -1.41, -1.60 |
Aspartate aminotransferase | P00504 | 0 | Amino acid catabolism | 1.16, -1.29, -1.96, 1.18 |
Glycine decarboxylase | P15505 | 2E-10 | Glycine catabolism | 1.24, -1.36, -1.89, 1.38 |
Neutral and basic amino acid transport protein rBAT | Q07837 | 6E-85 | Cystine reabsorption | 1.62, -1.14, -1.30, -1.22 |
Fructose-biphosphate aldolase, muscle type | P53445 | 6E-26 | Glycolysis | -1.26, -1.34,-1.61, -2.63 |
Cytochrome c oxidase subunit IV isoform 2 | P80971 | 4E-66 | Mitochondrial respiration | -1.27, -1.29, -1.69, -2.02 |
NADH-ubiquinone oxidoreductase subunit B14.5b | Q9CQ54 | 7E-19 | Mitochondrial respiration | 1.37, -2.22, -1.92, 1.74 |
Hemopexin | P02790 | 2E-44 | Heme transport | -1.22, -1.40, -2.08, -1.65 |
Solute carrier organic anion transporter family member 1C1 | Q9EPZ7 | 1E-23 | Ion transport | -1.02, -1.85, -1.39, -1.07 |
Alcohol dehydrogenase 1 | P26325 | 3E-92 | Oxidoreductase activity/xenobiotic metabolism | -1.07, -2.38, -2.63, -5.55 |
17-β-hydroxysteroid dehydrogenase 11 | Q6AYS8 | 4E-49 | Oxidoreductase activity/xenobiotic metabolism | 1.53, -2.63, -1.82, 2.07 |
Cytochrome P450 1A1 | O42457 | 0 | Oxidoreductase activity/xenobiotic metabolism | -1.72, -4.35, -2.00, -1.57 |
Cytochrome P450 2J1 | P52786 | 3E-69 | Oxidoreductase activity/xenobiotic metabolism | 1.02, -1.54, -1.06, -1.28 |
Cytochrome P450 2J2 | P51589 | 7E-63 | Oxidoreductase activity/xenobiotic metabolism | 1.01, -1.59, 1.02, -1.15 |
Cytochrome P450 2J6 | O54750 | 2E-87 | Oxidoreductase activity/xenobiotic metabolism | 1.34, -1.82, -2.00, -2.50 |
Glutathione S-transferase 3 | P26697 | 2E-63 | Oxidoreductase activity/xenobiotic metabolism | -1.15, -1.79, -1.54, -1.89 |
Monoamine oxidase | P49253 | 4E-66 | Oxidoreductase activity/xenobiotic metabolism | 1.28, -1.82, -1.75, -1.59 |
Retinol-binding protein II, cellular | P50120 | 1E-51 | Oxidoreductase activity/xenobiotic metabolism | -1.23, -3.33, -3.03, -1.10 |
α-2-HS-glycoprotein | Q9N2D0 | 2E-33 | Acute immune response | -1.13, -1.59, -1.85, -2.17 |
Ig heavy chain Mem5 | P84751 | 4E-38 | Antigen binding | -1.30, -1.07, 1.03, -2.38 |
B-F histocompatibility F10 antigen | P15979 | 4E-41 | Antigen processing | -1.15, 1.05, -1.45, -1.52 |
H-2 class II histocompatibility antigen, A-K α chain | P01910 | 7E-25 | Antigen processing | -1.28, -1.03, -1.30, -1.19 |
Fucolectin-1 (lectin pathway) | Q9I931 | 3E-37 | Complement activation | 1.04, -1.32, -1.35, -1.89 |
Histamine N-methyltransferase | P50135 | 3E-75 | Histamine metabolism | -1.08, -1.69, -1.53, -2.17 |
Macrophage migration inhibitory factor | P80177 | 1E-40 | Inflammatory response | -1.37, -1.37, -1.02, -1.48 |
Interferon regulatory factor 8 | Q90871 | 1E-15 | Interferon signalling | 1.01, -1.67, -2.94, 1.28 |
Centaurin-α 2 | Q9NPF8 | 3E-28 | GTPase activator | -1.23, -1.37, -1.03, -2.22 |
Collagen α1(I) chain | P02457 | 4E-68 | Collagen component | 1.43, -1.82, -1.72, -1.24 |
Gastrulation-specific G12-like protein | Q9CQ20 | 4E-18 | Microtubule depolymerization, inhibition | -1.01, -1.79, -1.89, -1.08 |
Plakophilin-3 | Q9QY23 | 8E-26 | Cell adhesion | -1.45, -1.67, -1.56, 1.01 |
Radixin | P26043 | 1E-24 | Actin filament capping | 1.32, -3.23, -2.04, -1.83 |
Transmembrane protein 59 | Q9QY73 | 8E-69 | Membrane-bound protein | -1.36, -1.41, -1.25, -2.08 |