Figure 1

(A) and (B). Inverse regulation of major metabolic and cell signaling KEGG pathways. For 20 different human tissues, KEGG pathways were compared between the ten samples displaying the highest and the lowest values of OXPHOS gene expression (study and sample characteristics are listed in Additional Files 2 and 3). The directional regulation of 200 major KEGG pathways (number of up- minus down-regulated genes in a given KEGG pathway normalized to the total number of regulated genes within a study) was color-coded with yellow and blue representing low and high expression of the pathways, respectively. KEGG pathways were then sorted according to their similarity to "oxidative phosphorylation" which is represented by the first row (labeled OXPHOS). Metabolic pathways were consistently positively correlated with each other and negatively correlated with the expression of cell signaling pathways. ALA+ASP metabolism = alanine and aspartate metabolism.