Figure 3

Phylogenetic tree of the conserved catalytic domains of metacaspases. The phylogenetic tree of metacaspase catalytic domains was constructed as described in Methods section. Bootstrap values >50% are indicated on the branches (1000 replicates). Cyanobacterial metacaspase gene IDs and the strain names are as in Table 2 and Table 1, separately. Strain names, families and additional domains are also given following the IDs. The green and grey boxes indicate Clade I and II, separately. MCAs containing the His/Cys mutation are marked in pink. MCAs from subfamily cbMC α are marked in green. Major additional domains from cbMC β are marked in color: orange-WD40, grey-signalling domains, and red-DUF323. MCAs from different species are marked in color: blue-eukaryotic plankton, yellow-eubacteria except cyanobacteria.