Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Table 2 Analysis of putative 5'UR TFBSs

TFBS	# genes	ER	NC	p-value
(A)
IRF/ISRE	40	1.41	3.20	0.0011
(B)
IRF/ISRE	40	1.53	3.99	0.0001
127	35	1.19	1.60	0.0006
CHX10	160	1.09	0.80	0.0001
IPF1 = PDX1	108	1.08	0.72	0.0010
TATA	280	1.07	0.67	0.0005
174	176	1.06	0.56	0.0009
NF-AT	519	1.03	0.25	0.0011
(C)
115	33	1.13	0.73	0.0006
POU1F1	49	1.12	0.65	0.0019
IPF1 = PDX1	108	1.08	0.45	0.0003
FOXF2	171	1.07	0.40	0.0018
CHX10	160	1.06	0.35	0.0010
TATA	280	1.06	0.33	0.0005

We assigned genes to 174 classes of putative TFBSs, either identified by their name, the major transcription factor binding to them, or their number in Xie et al. [14]. The table shows the number of genes in each TFBS class, approximate mean expression ratios (ER), mean normed coefficients (NC), and p-values from t-tests. (A) Basal differences between genotypes, (B) LPS induction in Wt, and (C) differences between genotypes in LPS induction (genotype by treatment interaction).

ISSN: 1471-2164