Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Table 3 Analysis of 3'UTR regulatory sequences

3'UTR motif	gene #	ER	NC	p-value
(A)
m57	110	1.04	0.39	0.0037
m11	623	0.98	-0.23	0.0026
m43	254	0.96	-0.33	0.0009
o7	207	0.96	-0.33	0.0058
(B)
m53	42	1.30	2.60	0.0076
o34	75	1.13	1.22	0.0006
m35	54	1.13	1.18	0.0026
m103	41	1.11	1.05	0.0048
m33	119	1.11	1.04	0.0026
m95	56	1.11	1.03	0.0004
m16	213	1.10	0.99	0.0000
o25	105	1.09	0.86	0.0011
m85	82	1.09	0.84	0.0043
m2/ARE	675	1.09	0.82	0.0000
m67	164	1.07	0.68	0.0004
o18	278	1.07	0.65	0.0001
m50	108	1.07	0.64	0.0081
m100	70	1.06	0.60	0.0079
o43	142	1.05	0.49	0.0021
m30	85	1.05	0.49	0.0133
m70	136	1.05	0.48	0.0108
o12	196	1.05	0.48	0.0012
m24	332	1.05	0.47	0.0001
o15	253	1.04	0.43	0.0011
m3	481	1.04	0.43	0.0000
m20	262	1.04	0.40	0.0024
o38	142	1.04	0.38	0.0063
m29	232	1.04	0.37	0.0013
m41	224	1.04	0.36	0.0025
o32	155	1.04	0.36	0.0067
m13	1015	1.03	0.30	0.0000
m4	625	1.03	0.29	0.0000
o21	363	1.03	0.26	0.0011
m19	308	1.02	0.25	0.0028
m9	942	1.02	0.24	0.0000
m31	347	1.02	0.21	0.0018
m25	488	1.02	0.21	0.0006
m8	337	1.02	0.17	0.0077
m26	383	1.02	0.15	0.0017
m5	1175	1.01	0.06	0.0000
m1/poly-A	1938	0.95	-0.54	0.0091
(C)
m91	66	1.1	0.56	0.0046
m13	1015	1.01	0.06	0.0016
m9	942	1.01	0.06	0.0016

A total of 175 3'UTR motis were identified as described in Xie et al. [14]. The table shows the number of genes in each class of motif, approximate mean expression ratios (ER), mean normed coefficients (NC), and p-values from t-tests. (A) Basal differences between genotypes, (B) LPS induction in Wt, and (C) differences between genotypes in LPS induction (genotype by treatment interaction).

ISSN: 1471-2164