Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles

Table 1 Gene Ontology categories enriched in KCl-responsive genes.

GO Category	Total genes†	Changed genes*	P value#
KCl-induced genes (284)
Response to stress	582	42	0.004
Oxidoreductase activity	322	33	2.11e-5
Carbohydrate metabolic process	266	28	5.77e-5
Generation of precursor metabolites and energy	180	18	0.002
Vacuole cell cycle-correlated morphology	165	17	0.002
Cofactor metabolic process	176	17	0.004
Ion homeostasis	121	12	0.013
Glucose metabolic process	88	11	0.003
KCl-repressed genes (341)
Gene expression	1438	150	2.81e-16
Protein metabolic process	1449	120	4.93e-06
Translation	399	101	2.48e-41
Structural constituent of ribosome	221	80	4.804e-45
Ribosome biogenesis and assembly	356	70	5.11e-21
Organic acid metabolic process	386	51	1.28e-08
Carboxylic acid metabolic process	386	51	1.28e-08
RNA binding	476	50	2.04e-05
Oxidoreductase activity	322	32	0.001
Protein-RNA complex assembly	140	29	1.08e-09
Amino acid biosynthetic process	134	23	2.11e-06
Cofactor binding	156	20	0.001
Lyase activity	96	14	0.001
Glutamine family amino acid metabolic process	61	11	0.001
Vitamin binding	61	11	0.001

† Total genes in the GO category.
*Number of KCl induced of reduced genes in the GO category.
# p-value from a Fisher's Extract Test (one-sided), statistical considerations are fully discussed in [44].

ISSN: 1471-2164