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Table 2 List of anticorrelated genes

From: Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor

SCO ID Definition Pathway r
SCO2286 alkaline phosphatase folate biosynthesis --0.80
SCO3249 [acyl-carrier-protein] S-malonyltransferase fatty acid biosynthesis --0.78
SCO5887 [acyl-carrier-protein] S-malonyltransferase fatty acid biosynthesis --0.75
SCO0386 asparagine synthetase (glutamine-hydrolysing) aspartate metabolism --0.75
SCO3248 pentadecanoyl-[acyl-carrier protein] synthesis fatty acid biosynthesis --0.74
SCO5886 pentadecanoyl-[acyl-carrier protein] synthesis fatty acid biosynthesis --0.71
SCO5888 pentadecanoyl-[acyl-carrier protein] synthesis fatty acid biosynthesis --0.70
SCO0828 alkaline phosphatase folate biosynthesis --0.67
SCO2068 alkaline phosphatase folate biosynthesis --0.66
SCO3246 pentadecanoyl-[acyl-carrier protein] synthesis fatty acid biosynthesis --0.63
SCO3595 D-alanine-D-alanine ligase D-alanine metabolism --0.63
SCO3221 prephenate dehydrogenase tryptophan biosynthesis --0.63
SCO6655 GTP cyclohydrolase II riboflavin metabolism --0.61
SCO6787 butyryl-CoA dehydrogenase propanoate metabolism --0.59
SCO2687 GTP cyclohydrolase II riboflavin metabolism --0.52
  1. The most strongly anticorrelated genes are listed on the basis of correlation between gene expression and predicted flux (r < --0.25). Pathway annotations are based on the KEGG database without manual curation. Most of the genes belong to the pink or red cluster and are upregulated in stationary phase; these represent potential new genes involved in antibiotics biosynthesis. Several examples validating this interpretation are discussed in detail in the text.