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Table 4 GO terms significantly enriched amongst differentially expressed genes at 5 months

From: Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosis

Gene ontology term

No. of genes

Fold Enrichment

p value

Nervous system development

   

axon extension

6

8.1

0.0006

cell part morphogenesis

18

2.4

0.0010

cell projection organization and biogenesis

18

2.4

0.0010

cell projection morphogenesis

18

2.4

0.0010

regulation of axon extension

5

10.2

0.0010

regulation of axonogenesis

6

5.6

0.0035

regulation of neurogenesis

7

4.5

0.0040

cellular morphogenesis during differentiation

13

2.5

0.0055

positive regulation of cell adhesion

4

8.9

0.0087

axonogenesis

11

2.6

0.0090

neurite development

13

2.3

0.0093

nervous system development

27

1.7

0.0105

cell morphogenesis

23

1.7

0.0135

cellular structure morphogenesis

23

1.7

0.0135

neurite morphogenesis

11

2.4

0.0175

neuron morphogenesis during differentiation

11

2.4

0.0175

neuron development

13

2.1

0.0183

microtubule-based process

12

2.1

0.0249

negative regulation of axon extension

3

10.5

0.0304

neuron differentiation

14

1.9

0.0346

negative regulation of neurogenesis

4

5.4

0.0348

Neurogenesis

16

1.7

0.0403

cell migration

13

1.9

0.0413

generation of neurons

15

1.8

0.0457

negative regulation of axonogenesis

3

8.1

0.0493

Cholesterol metabolism

   

cholesterol metabolic process

7

3.9

0.0083

steroid biosynthetic process

8

4.3

0.0021

sterol biosynthetic process

6

5.9

0.0030

sterol metabolic process

8

3.9

0.0039

steroid metabolic process

10

2.9

0.0064

cholesterol biosynthetic process

5

6.1

0.0078

RNA metabolism

   

nuclear mRNA splicing, via spliceosome

7

3.4

0.0153

RNA splicing, via transesterification reactions

7

3.4

0.0153

Energy production

   

generation of precursor metabolites and energy

20

1.7

0.0282

Other

   

protein import

8

3.3

0.0106

leukocyte migration

4

8.1

0.0112

protein import into nucleus

7

3.6

0.0115

leukocyte migration

4

8.1

0.0112

protein import into nucleus

7

3.6

0.0115

nuclear import

7

3.5

0.0140

nucleocytoplasmic transport

9

2.5

0.0249

feeding behaviour

4

6.1

0.0253

nuclear transport

9

2.5

0.0265

alcohol metabolic process

14

1.9

0.0296