Table 8 Differentially expressed genes in the category of 'Nervous system development'

Neurite outgrowth

1428393

neuritin 1

Nrn1

0.0090

3.82

down

14 months

1428089

SLIT and NTRK-like family, member 1

Slitrk1

0.0156

1.35

down

5 months

1416666

serine peptidase inhibitor, clade E, member 2

Serpine2

0.0414

1.65

down

5 months

1437308

coagulation factor II (thrombin) receptor

F2r

0.0346

1.59

up

3 months

1437308

coagulation factor II (thrombin) receptor

F2r

0.0286

1.22

up

5 months

1455252

tuberous sclerosis 1

Tsc1

0.0073

1.37

up

5 months

1422600

RAS protein-specific guanine nucleotide-releasing factor 1

Rasgrf1

0.0011

1.63

down

14 months

1435614

RAS protein-specific guanine nucleotide-releasing factor 1

Rasgrf1

0.0002

1.44

down

14 months

1455027

RUN and FYVE domain containing 2

Rufy3

0.0360

1.43

down

5 months

1424402

RUN and FYVE domain containing 2

Rufy3

0.0382

1.32

down

5 months

1452342

amyloid beta precursor protein-binding, family B, member 2

Apbb2

0.0415

1.21

down

14 months

1449439

Kruppel-like factor 7 (ubiquitous)

Klf7

0.0008

1.62

down

5 months

Growth factor signalling pathways

1420838

neurotrophic tyrosine kinase, receptor, type 2

Ntrk2

0.0067

1.29

down

5 months

1418057

T-cell lymphoma invasion and metastasis 1

Tiam1

0.0006

1.66

down

5 months

1418057

T-cell lymphoma invasion and metastasis 1

Tiam1

0.0031

1.43

down

14 months

1439015

glial cell line derived neurotrophic factor receptor alpha 1

Gfra1

0.0454

1.95

down

5 months

1455018

lemur tyrosine kinase 2

Lmtk2

0.0107

1.32

down

14 months

TGFß signalling pathway

1450923

transforming growth factor, beta 2

Tgfb2

0.0397

1.47

down

5 months

1450839

DNA segment, human D4S114

D0H4S114

0.0093

2.00

down

3 months

1450839

DNA segment, human D4S114

D0H4S114

0.0190

1.98

down

5 months

1450839

DNA segment, human D4S114

D0H4S114

0.0025

1.50

down

14 months

1422487

MAD homolog 4 (Drosophila)

Smad4

0.0368

1.41

down

5 months

1452143

spectrin beta 2

Spnb2

0.0023

1.21

down

5 months

1425116

spectrin beta 4

Spnb4

0.0463

1.14

up

14 months

Rho-GTPase pathway

1416329

cytoplasmic FMR1 interacting protein 1

Cyfip1

0.0158

1.36

down

5 months

1448600

vav 3 oncogene

Vav3

0.0304

1.32

down

5 months

Microtubule-based processes

1455719

tubulin, beta 5

Tubb5

0.0034

1.60

down

5 months

1421851

microtubule-associated protein 1 B

Mtap1b

0.0142

2.10

down

5 months

1457316

microtubule-associated protein 6

Mtap6

0.0105

1.75

down

5 months

1424719

microtubule-associated protein tau

Mapt

0.0482

1.50

down

5 months

1417005

kinesin 2

Kns2

0.0484

1.17

down

5 months

1433926

dynein, cytoplasmic, light intermediate chain 2

Dnclic2

0.0121

1.36

down

5 months

1437875

bicaudal D homolog 2

Bicd2

0.0236

1.45

down

5 months

1451630

tubulin tyrosine ligase

Ttl

0.0016

1.45

down

5 months

1428282

tubulin-specific chaperone e

Tbce

0.0348

1.24

down

14 months

1423626

dystonin

Dst

0.0358

1.24

down

5 months

Axon guidance

1418084

neuropilin 1

Nrp1

0.0092

2.02

down

5 months

1448944

neuropilin 1

Nrp1

0.0151

1.58

down

5 months

1456778

neuropilin 2

Nrp2

0.0020

1.28

down

5 months

1420416

semaphorin 3A

Sema3a

0.0010

1.35

down

5 months

1420416

semaphorin 3A

Sema3a

0.0341

1.26

down

14 months

1415877

dihydropyrimidinase-like 3

Dpysl3

0.0461

2.25

down

5 months

1450863

double cortin and calcium/calmodulin-dependent protein kinase-like 1

Dcamkl1

0.0364

1.29

down

5 months

Synapse formation and plasticity

1427898

ring finger protein (C3H2C3 type) 6

Rnf6

0.0182

1.59

down

5 months

1452004

calcitonin-related polypeptide, alpha

Calca

0.0283

1.26

down

5 months

1422639

calcitonin-related polypeptide, beta

Calcb

0.0389

1.78

down

5 months

1449465

reelin

Reln

0.0006

2.38

down

3 months

1423100

FBJ osteosarcoma oncogene

Fos

0.0313

2.32

down

3 months

1423100

FBJ osteosarcoma oncogene

Fos

0.0123

2.17

down

5 months

1452901

cAMP responsive element binding protein 1

Creb1

0.0148

1.44

down

14 months

Wingless signalling pathway

1437301

dishevelled, dsh homolog 1 (Drosophila)

Dvl1

0.0166

1.38

down

14 months

1434439

glycogen synthase kinase 3 beta

Gsk3b

0.0023

1.23

down

14 months

1437351

CXXC finger 4

Cxxc4

0.0462

1.37

down

5 months

1437351

CXXC finger 4

Cxxc4

0.0341

1.30

down

14 months

Cell adhesion molecules

1437466

activated leukocyte cell adhesion molecule

Alcam

0.0329

1.94

down

5 months

1437467

activated leukocyte cell adhesion molecule

Alcam

0.0233

1.60

down

5 months

1437466

activated leukocyte cell adhesion molecule

Alcam

0.0400

1.65

down

14 months

1426301

activated leukocyte cell adhesion molecule

Alcam

0.0045

1.51

down

14 months

1437467

activated leukocyte cell adhesion molecule

Alcam

0.0414

1.50

down

14 months

1416034

CD24a antigen

Cd24a

0.0165

1.96

down

5 months

1416891

numb gene homolog (Drosophila)

Numb

0.0394

1.45

down

14 months

1424954

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

Pip5k1c

0.0166

1.14

down

14 months

1418615

astrotactin 1

Astn1

0.0461

1.65

down

5 months

1416474

immunoglobulin superfamily, DCC subclass, member 4

Igdcc4

0.0342

1.19

down

5 months

1449286

netrin G1

Ntng1

0.0119

1.87

down

14 months

1442659

protocadherin 9

Pcdh9

0.0166

1.64

down

14 months

1420429

protocadherin beta 3

Pcdhb3

0.0365

1.89

down

14 months

1425092

cadherin 10

Cdh10

0.0208

1.39

down

14 months

1433788

neurexin III

Nrxn3

0.0021

1.78

down

14 months

1422798

contactin associated protein-like 2

Cntnap2

0.0077

1.37

down

5 months

1417378

synaptic cell adhesion molecule

Syncam

0.0400

1.40

down

14 months

1417377

synaptic cell adhesion molecule

Syncam

0.0191

1.38

down

14 months

1422445

integrin alpha 6

Itga6

0.0221

1.50

down

5 months

Others

1457015

Neurofilament 3, medium

Nef3

0.0209

1.40

up

14 months

1416533

EGL nine homolog 2

Egln2

0.0203

1.46

down

5 months

1420475

myotrophin

Mtpn

0.0120

1.67

down

5 months

1417133

peripheral myelin protein

Pmp22

0.0159

1.89

down

5 months

1449353

wild-type p53-induced gene 1

Wig1

0.0249

1.57

down

5 months

1417624

Ngfi-A binding protein 1

Nab1

0.0119

1.44

down

5 months