Figure 8

Comparison of the tissue expression patterns of the seven 8q24.3 ZNF genes and those of ten ZNF genes located on other human chromosomes by hierarchical cluster analysis. The RNA expression profiles are based on quantitative RT-PCR with total RNA from the indicated tissues as input (see Figure 7). The trees were calculated with the original relative expression data. The gene tree is based on the Pearson correlation distance and the tissue tree on Euclidian distance, both with single linkage. For the visual heatmap the data were standardized in order to fit them into the same scale, however, without changing the trees. Pseudo-color dark blue marks lowest, dark red highest expression. In addition to the gene names chromosomal localizations are indicated. The assignment of ZNF genes into tissue subgroups is based on subclades of the gene clustering and is consistent with Figure 7.