Schematic representation of significant changes on the transcriptome level between high and low osmolarity cultivation of P. pastoris in carbon limited chemostats. Wt strain (A). 3H6 Fab expressing strain (B). Only statistically significant genes are represented (cut-off q < 0.05). Blue downward arrows indicate down-regulation of genes at high osmolarity. Red upward arrows indicate up-regulated genes at high osmolarity. No arrow indicates no significant regulation of the genes or gene groups.