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Table 1 Subgroups of up-regulated genes.

From: Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes

Group Group Size (probe sets) Group Size (Genes) NF-κB target genes (Bioinf) NF-κB target genes (Lit) ARE
IL-17 2 2 - - -
TNF/IL-17 21 21 8 (38%) 1 (5%) 9 (43%)
IL1 + IL17 6 6 - - -
IL1 + TNF 141 135 23 (17%) 8 (6%) 24 (18%)
IL1 + TNF/IL17 89 80 9 (11%) 18 (23%) 15 (19%)
IL-17 + TNF/IL17 4 4 - - -
IL17 + TNF 4 4 - - -
TNF + TNF/IL17 17 16 - - -
TNF + IL1 + TNF/IL17 177 151 39 (26%) 35 (23%) 25 (17%)
TNF + IL17 + TNF/IL17 2 2 - - -
IL1 + IL17 + TNF/IL17 12 10 - - -
TNF + IL1 + IL17 14 14 - - -
Up-regulated by all stimuli
(TNF/IL-17, IL-17, TNF, IL-1)
48 40 23 (58%) 21 (53%) 15 (38%)
All expressed genesa 14.988 9.828 1369(14%) 311 (3%) 2076 (21%)
  1. Probe sets and gene numbers are indicated as well as frequency of NF-κB transcription factor binding site (separated for the bioinformatic and literature based approach) and the frequency of AU rich elements (ARE). Groups with less than 20 genes have been excluded from the analysis.
  2. a This group comprises all genes which show at least one valid expression value