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Table 2 Gene expression changes for DNA damage response and cell cycle genes in WT and Rad54/Rad54B MEFs after exposure to mutagens and clastogens.

From: Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells

Gene symbol Alias WT1- N-ac-AAF Rad2- N-ac-AAF WT - ENU Rad - ENU WT - BLM Rad - BLM WT - MMC Rad - MMC
Pmaip1 Noxa 3.26* 2.40 1.39 1.29 4.12* 2.86* 2.26 -1.02
Ccng1   2.74* 2.00* 1.77 1.28 2.99* 2.13* 1.54 -1.11
Btg2   2.46* 1.68* 1.59 1.09 2.77* 1.75* 1.55 1.13
Mdm2   6.37* 3.40* 2.21 1.54 3.08* 1.95* 1.99 1.08
Cdkn1a P21 4.20* 2.81* 2.09 1.54 3.06* 2.00* 1.67 1.35
Rprm   2.41* 2.37* 1.21 1.31 2.50* 1.97* 1.14 1.38
Perp   1.54* 1.40 1.07 1.08 1.48 1.46 1.05 1.08
Bax   1.55* 1.52* 1.14 1.29 1.50 1.40 1.25 -1.05
Bbc3 Puma 1.34 1.24 1.16 1.10 1.54* 1.33 1.41 1.11
Mgmt   1.01 1.06 1.15 1.16 1.72* 1.29 1.07 -1.08
Ccnb1   -1.63* -1.78* 1.07 1.20 -1.6* -1.43 -1.58 -1.61
Ccnb2   -1.64* -1.56* -1.08 1.16 -1.67* -1.48 -1.79* -1.42
Plk1   -1.55 -1.72* 1.07 1.19 -2.00* -1.57* -2.04* -1.51
Ccna2   -1.24 -1.37 1.07 1.16 -2.01* -1.43 -1.58* -1.38
Ube2c   -1.25 -1.48 1.25 1.23 -1.44 -1.42 -1.70* -1.58
Aurka   -1.28 -1.59* 1.29 1.22 -1.81* -1.50* -1.71* -1.58*
Cdkn3   -1.44 -1.45 -1.01 1.16 -1.48 -1.22 -1.53* -1.24
Cdca3   -1.31 -1.39 -1.00 1.17 -1.51* -1.32 -1.44 -1.38
Cdc2a   -1.16 -1.22 1.18 1.27 -1.64* -1.33 -1.56* -1.44
Bub1b   -1.10 -1.31 1.10 1.07 -1.67* -1.43 -1.49 -1.27
Cdca8   -1.12 -1.29 1.17 1.11 -1.57* -1.32 -1.34 -1.35
Cdkn2d P19 -1.24 -1.17 1.10 1.45 -1.47 -1.26 -1.65* -1.04
Cdkn2c P18 1.05 -1.05 1.19 1.42 -1.59* -1.34 -1.60* -1.09
  1. 1WT are wild-type MEFs treated with the different compounds
  2. 2Rad are Rad54/Rad54B MEFs treated with the different compounds
  3. *An asterisk indicates a significant regulated gene (at FDR < 5% and ratio > ± 1.5)