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Table 2 Gene expression changes for DNA damage response and cell cycle genes in WT and Rad54/Rad54B MEFs after exposure to mutagens and clastogens.

From: Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells

Gene symbol

Alias

WT1- N-ac-AAF

Rad2- N-ac-AAF

WT - ENU

Rad - ENU

WT - BLM

Rad - BLM

WT - MMC

Rad - MMC

Pmaip1

Noxa

3.26*

2.40

1.39

1.29

4.12*

2.86*

2.26

-1.02

Ccng1

 

2.74*

2.00*

1.77

1.28

2.99*

2.13*

1.54

-1.11

Btg2

 

2.46*

1.68*

1.59

1.09

2.77*

1.75*

1.55

1.13

Mdm2

 

6.37*

3.40*

2.21

1.54

3.08*

1.95*

1.99

1.08

Cdkn1a

P21

4.20*

2.81*

2.09

1.54

3.06*

2.00*

1.67

1.35

Rprm

 

2.41*

2.37*

1.21

1.31

2.50*

1.97*

1.14

1.38

Perp

 

1.54*

1.40

1.07

1.08

1.48

1.46

1.05

1.08

Bax

 

1.55*

1.52*

1.14

1.29

1.50

1.40

1.25

-1.05

Bbc3

Puma

1.34

1.24

1.16

1.10

1.54*

1.33

1.41

1.11

Mgmt

 

1.01

1.06

1.15

1.16

1.72*

1.29

1.07

-1.08

Ccnb1

 

-1.63*

-1.78*

1.07

1.20

-1.6*

-1.43

-1.58

-1.61

Ccnb2

 

-1.64*

-1.56*

-1.08

1.16

-1.67*

-1.48

-1.79*

-1.42

Plk1

 

-1.55

-1.72*

1.07

1.19

-2.00*

-1.57*

-2.04*

-1.51

Ccna2

 

-1.24

-1.37

1.07

1.16

-2.01*

-1.43

-1.58*

-1.38

Ube2c

 

-1.25

-1.48

1.25

1.23

-1.44

-1.42

-1.70*

-1.58

Aurka

 

-1.28

-1.59*

1.29

1.22

-1.81*

-1.50*

-1.71*

-1.58*

Cdkn3

 

-1.44

-1.45

-1.01

1.16

-1.48

-1.22

-1.53*

-1.24

Cdca3

 

-1.31

-1.39

-1.00

1.17

-1.51*

-1.32

-1.44

-1.38

Cdc2a

 

-1.16

-1.22

1.18

1.27

-1.64*

-1.33

-1.56*

-1.44

Bub1b

 

-1.10

-1.31

1.10

1.07

-1.67*

-1.43

-1.49

-1.27

Cdca8

 

-1.12

-1.29

1.17

1.11

-1.57*

-1.32

-1.34

-1.35

Cdkn2d

P19

-1.24

-1.17

1.10

1.45

-1.47

-1.26

-1.65*

-1.04

Cdkn2c

P18

1.05

-1.05

1.19

1.42

-1.59*

-1.34

-1.60*

-1.09

  1. 1WT are wild-type MEFs treated with the different compounds
  2. 2Rad are Rad54/Rad54B MEFs treated with the different compounds
  3. *An asterisk indicates a significant regulated gene (at FDR < 5% and ratio > ± 1.5)