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Table 3 The expression of 26 genes in the very early stage of fulminant hepatitits mice model by real-time RT-PCR

From: Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model

genes Number ΔΔct (1 h/control) ΔΔct (3 h/control) ΔΔct (6 h/control) ΔΔct (12 h/control)
ACSL1 12 1.58 ± 1.72 2.21 ± 3.81 0.47 ± 0.55# 0.71 ± 1.46
ALDH8A1 12 1.26 ± 0.62 5.16 ± 9.96 16.47 ± 40.57 2.78 ± 3.74
CMTM8 12 4.24 ± 5.47 60.46 ± 127.18 48.60 ± 111.88 62.93 ± 106.90
COLEC11 12 0.73 ± 0.29# 4.04 ± 2.35#* 3.27 ± 4.40 1.50 ± 2.00&
COLEC12 12 1.19 ± 0.54 3.86 ± 3.41#* 2.44 ± 2.77 6.59 ± 12.03
DPP4 12 0.87 ± 0.60 11.64 ± 6.76#* 14.91 ± 14.25#* 86.16 ± 218.29
FBXO3 12 1.79 ± 1.59 2.13 ± 1.91 1.64 ± 1.54 1.09 ± 0.72
FN3K 12 1.60 ± 1.98 3.38 ± 2.88# 2.01 ± 1.96 2.20 ± 3.57
GPD1L 12 2.61 ± 3.59 0.76 ± 0.83# 0.35 ± 0.30# 1.25 ± 3.02
HLF 12 1.49 ± 1.39 8.15 ± 10.11*# 4.26 ± 5.27 3.72 ± 5.31
KLB 12 1.01 ± 0.51 1.93 ± 1.11*# 2.93 ± 5.05 1.58 ± 1.91
MAP2K6 12 2.61 ± 1.75# 31.29 ± 90.44 0.94 ± 1.188* 1.40 ± 2.07
MPDZ 12 3.02 ± 2.23# 6.28 ± 4.92# 3.96 ± 5.98 5.11 ± 6.11
MTAP 12 1.77 ± 0.74# 11.75 ± 31.48 3.81 ± 8.55 1.56 ± 1.56
MSRB2 12 1.77 ± 1.60 7.07 ± 5.81#* 2.38 ± 2.35& 3.34 ± 3.52#
ORMDL1 12 1.15 ± 0.91 2.85 ± 1.81#* 1.57 ± 0.86& 1.23 ± 0.50&
POLG2 12 0.71 ± 0.51 5.74 ± 9.951 3.07 ± 3.28* 1.46 ± 0.84*
STARD5 12 1.39 ± 1.20 2.58 ± 5.52 2.09 ± 2.91 2.52 ± 1.03#*
PARD3 12 1.24 ± 1.50 6.74 ± 11.47 3.83 ± 4.79 2.05 ± 2.39
SLC29A1 12 0.82 ± 0.44 1.75 ± 1.35* 1.16 ± 1.71 0.33 ± 0.29#*&
SOX5 12 0.91 ± 0.65 1.56 ± 0.63#* 0.85 ± 0.52& 3.25 ± 3.84
TERT 12 0.82 ± 0.70 2.71 ± 2.52#* 1.89 ± 2.55 1.09 ± 2.22
CAR5A 12 1.87 ± 2.61 2.56 ± 3.16 0.54 ± 0.57# 0.45 ± 0.63#&
FASTKD1 12 0.38 ± 0.26# 1.75 ± 1.35* 0.95 ± 0.50* 0.46 ± 0.30#&
PDE7B 12 0.64 ± 0.40# 1.39 ± 2.18 0.44 ± 0.33# 0.59 ± 0.33#
FASTKD1 12 0.96 ± 0.96 1.90 ± 1.04#* 0.63 ± 0.44#& 0.60 ± 0.49#&
  1. #: Compared with 0 h, the difference was significant (p < 0.05)
  2. *: Compared with 1 h, the difference was significant (p < 0.05)
  3. &: Compared with 3 h, the difference was significant (p < 0.05)
  4. : Compared with 6 h, the difference was significant (p < 0.05)
  5. Compared with normal controls, the expression of most of the 26 genes showed a statistical significant change (p < 0.05). Expressions of PARD3, ALDH8A1, CMTM8 and FBXO3 were also higher than those of normal controls, but there was no statistical significance (p > 0.05)