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Table 1 PGE2-synthesizing enzymes and differentially expressed genes in selected significant GO categories (1-3 h).

From: Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

Symbol Gene Name M-valuea Fold Change p value
PGE 2 -synthesizing enzymes
PTGES microsomal prostaglandin E synthase-1 (probe 1) 0.65 1.6 2.4 × 10-4
PTGES microsomal prostaglandin E synthase-1 (probe 2) 0.39 1.3 0.09b
PTGES2 microsomal prostaglandin E synthase-2 -0.03 1.0 1.00b
PTGES3 cytosolic prostaglandin E synthase (probe 1) 0.03 1.0 1.00b
PTGES3 cytosolic prostaglandin E synthase (probe 2) 0.16 1.1 0.98b
PTGS2 cyclooxygenase-2 0.50 1.4 0.63b
GO category: Positive regulation of I-kappaB kinase/NF-kappaB cascade
APOL3 apolipoprotein L, 3 1.24 2.4 1.2 × 10-8
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.63 1.5 5.1 × 10-4
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.50 1.4 3.9 × 10-4
FLNA filamin A, alpha (actin binding protein 280) -0.23 -1.2 0.03
NUP62 nucleoporin 62 kDa 0.35 1.3 1.0 × 10-5
NUP62 nucleoporin 62 kDa 0.37 1.3 9.5 × 10-3
TICAM2 toll-like receptor adaptor molecule 2 0.36 1.3 1.6 × 10-3
CD40 CD40 molecule, TNF receptor superfamily member 5 0.40 1.3 3.6 × 10-3
TLR3 toll-like receptor 3 0.40 1.3 0.01
TFG TRK-fused gene 0.27 1.2 0.04
F2R coagulation factor II (thrombin) receptor -0.22 -1.2 0.05
RIPK2 receptor-interacting serine-threonine kinase 2 1.14 2.2 1.7 × 10-6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.35 1.3 1.5 × 10-3
TNF tumor necrosis factor (TNF superfamily, member 2) -0.46 -1.4 2.1 × 10-3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -1.17 -2.3 1.4 × 10-3
TRIM38 tripartite motif-containing 38 0.33 1.3 0.04
BIRC2 baculoviral IAP repeat-containing 2 0.62 1.5 4.8 × 10-3
GJA1 gap junction protein, alpha 1, 43 kDa -0.64 -1.6 0.02
RELA v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) 0.47 1.4 1.6 × 10-4
GO category: Positive regulation of JNK cascade
EDA2R ectodysplasin A2 receptor -0.34 -1.3 1.3 × 10-3
TLR3 toll-like receptor 3 0.40 1.3 0.01
TAOK3 TAO kinase 3 -0.35 -1.3 0.01
TAOK3 TAO kinase 3 -0.28 -1.2 9.0 × 10-3
HIPK2 homeodomain interacting protein kinase 2 0.40 1.3 3.4 × 10-5
TNF tumor necrosis factor (TNF superfamily, member 2) -0.46 -1.4 2.1 × 10-3
  1. PGE2-synthesizing enzymes and differentially expressed genes in selected significant GO categories when comparing 1 h and 3 h of TNFα treatment. aPositive M-values indicate genes up-regulated by TNFα, and negative M-values indicate genes down-regulated by TNFα between the 1 h and 3 h time points. bNot differentially expressed in the comparison between time-points 1 h and 3 h. Differential expression is defined as p < 0.05.