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Table 2 Differential expression of PGE2-synthesizing enzymes when comparing 1 h and 6 h of TNFα treatment.

From: Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

Symbol Gene Name M-valuea Fold Change p value
PTGES microsomal prostaglandin E synthase-1 (probe 1) 0.87 1.8 6.2 × 10-7
PTGES microsomal prostaglandin E synthase-1 (probe 2) 0.54 1.5 1.8 × 10-3
PTGES2 microsomal prostaglandin E synthase-2 -0.06 1.0 0.83b
PTGES3 cytosolic prostaglandin E synthase (probe 1) 0.03 1.0 0.78b
PTGES3 cytosolic prostaglandin E synthase (probe 2) 0.03 1.0 0.98b
PTGS2 cyclooxygenase-2 0.85 1.8 0.03
  1. aPositive M-values indicate up-regulated genes, and negative M-values indicate down-regulated genes. bNot differentially expressed in the comparison between time-points 1 h and 6 h. Differential expression is defined as p < 0.05.