Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

Table 2 Differential expression of PGE₂-synthesizing enzymes when comparing 1 h and 6 h of TNFα treatment.

Symbol	Gene Name	M-value^a	Fold Change	p value
PTGES	microsomal prostaglandin E synthase-1 (probe 1)	0.87	1.8	6.2 × 10^-7
PTGES	microsomal prostaglandin E synthase-1 (probe 2)	0.54	1.5	1.8 × 10^-3
PTGES2	microsomal prostaglandin E synthase-2	-0.06	1.0	0.83^b
PTGES3	cytosolic prostaglandin E synthase (probe 1)	0.03	1.0	0.78^b
PTGES3	cytosolic prostaglandin E synthase (probe 2)	0.03	1.0	0.98^b
PTGS2	cyclooxygenase-2	0.85	1.8	0.03

^aPositive M-values indicate up-regulated genes, and negative M-values indicate down-regulated genes. ^bNot differentially expressed in the comparison between time-points 1 h and 6 h. Differential expression is defined as p < 0.05.

ISSN: 1471-2164