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Table 3 DEFB copy numbers per diploid genome estimated by the ratio of 454 haplotype calls (run 1) in comparison to alternative methods.

From: Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing

  454 Alternative methods
Amplicon F2 F5 f F5 r F4 F6 F7 F8 Average Armour 5PRT PPRT MLPA Average 454-Altern.
MSVs 1-2 6-8 7-10a 3-5 11-15 16-18 19-24   ~       ~ ~
C0140 5   4   4 (2n) 4 4 4.20 4 4 3.78 4.19 4 3.99 4 0
C0766 3 3 3 4     3.25 3 3 2.75 3.31 3 3.01 3 0
C0913 3 3 3 3 3    3.00 3 3 3.00 3.13 3 3.03 3 0
NA12760 7 6 6 6 5 6 (2n) 6 (2n) 6.00 6 6 5.57 6.04 6 5.90 6 0
NA15029 6 (3n) 5 5 6 5 5 5 5.29 5 nd 4.70 5.58 5 5.09 5 0
NA15213 5 5 4 5 4 5 5 4.71 5 nd 4.18 4.18 4 4.12 4 +1
NA15385 5 7 5 7 5 6 (2n) 5 5.71 6 nd 5.29 5.17 5 5.15 5 +1
NA18502 10 10 9   7 9 (3n) 8 (4n) 8.83 9 8 8.98 nd 9 8.66 9 0
NA18552   5 6 (2n) 7     6.00 6 2 2.23 2.02 2 2.06 2 +4
NA18858 4   4 3   4 5 4.00 4 8 7.71 8.08 8 7.95 8 -4
NA19140 7   7   5 6   6.25 6 7 5.71 6.26 6 6.24 6 0
  1. Armour: PRT and MAPH/REDVR [36] and personal communication; 5PRT. PPRT [18, 28]; MLPA [28]. ~: rounded; n: multiple of the minimal estimated CN; *: CN estimations based on ultra-deep 454 sequencing; nd: no data; blank: non polymorphic.