Figure 2

Kinetics of gene induction in response to IL2. (A) Kinetic clusters of genes induced by IL2 treatment. Genes were divided into clusters according to the first time in which they were induced by at least 2.0-fold (numbers of genes in each cluster are depicted in inset). Mean expression patterns of the clusters are shown. To bring genes to a similar scale, for each gene, relative expression levels to t0 (in log scale) were normalized to the gene's maximal fold of induction. After such manipulation, genes with similar kinetics but different magnitude of response show similar pattern. (B) Comparison of T half-life distribution between the different kinetic clusters. (At the X-axis, the number of genes assigned to each kinetic cluster is indicated next to the time point indicator. (C) P-values (Wilcoxon test) for the comparison between each pair of clusters. T half-life distribution of early-induced genes was significantly lower than those of genes that were induced at slower pace.