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Table 1 Extent of overlap in transcript responses to TCDD among dioxin-sensitive and dioxin-resistant rat strains/lines

From: Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

   Sensitive Collective Score
   -2 -1 0 1 2
Resistant Collective Score -2 5 1 1 0 0
  -1 14 18 7 0 0
  0 26 177 8153 94 17
  1 0 0 30 12 26
  2 0 0 2 2 20
  1. To evaluate the overlap of significantly (padjusted < 0.01) altered transcripts between the sensitive and resistant collectives we formed a two-way table. A TCDD-responsive score of -1 (repressed), 0 (unchanged), or +1 (induced) was assigned to each gene in each strain. The sum of the scores for the sensitive strains/lines form the columns and the sum of the scores for the resistant strains/lines are the rows. Each value corresponds to the number of genes that exhibited a significant response to TCDD treatment. For example, 20 genes are induced in both sensitive and both resistant strains/lines, while 5 genes are repressed in both of the sensitive strains/lines and both of the resistant strains/lines. Of the 8605 genes examined, 452 genes responded in at least 1 strain/line, while 8153 genes did not respond to TCDD in any rat strain/line.