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Table 3 Type-II gene responses 19 hours after TCDD exposure

From: Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

Resistant Collective Sensitive Collective    
H/W LnA L-E LnC    
FC log2 padj FC log2 padj FC log2 padj FC log2 padj Gene ID Symbol Full Name
-0.3 7.3 × 10-2 -0.4 1.1 × 10-2 -0.7 5.7 × 10-4 -0.3 3.0 × 10-3 25368 Adk adenosine kinase
0.4 2.2 × 10-2 0.2 5.6 × 10-2 0.6 6.2 × 10-3 0.4 4.8 × 10-3 305338 Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2
-0.4 1.4 × 10-1 -0.3 6.8 × 10-2 -0.8 1.5 × 10-3 -0.5 2.9 × 10-3 25698 Ass1 argininosuccinate synthetase 1
0.3 7.3 × 10-2 0.4 1.1 × 10-2 0.4 7.3 × 10-3 0.4 1.4 × 10-3 116550 Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
-0.9 6.5 × 10-2 -0.6 4.8 × 10-2 -0.9 4.3 × 10-3 -0.8 4.5 × 10-3 64828 B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1
0.3 1.6 × 10-1 0.2 6.0 × 10-2 0.6 4.3 × 10-3 0.7 1.5 × 10-3 113948 Bbs2 Bardet-Biedl syndrome 2 homolog (human)
0.3 3.0 × 10-1 0.5 5.7 × 10-2 0.5 1.0 × 10-3 0.6 2.2 × 10-3 292027 Cfdp1 craniofacial development protein 1
-0.2 2.3 × 10-1 -0.3 7.1 × 10-2 -0.6 1.0 × 10-3 -0.6 1.5 × 10-3 85251 Col18a1 collagen, type XVIII, alpha 1
-0.3 3.2 × 10-1 -0.5 6.6 × 10-2 -0.9 1.7 × 10-4 -0.4 9.4 × 10-3 266682 Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2
-0.4 2.8 × 10-1 -0.5 3.3 × 10-2 -0.9 7.8 × 10-5 -0.5 2.2 × 10-3 286904 Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4
0.4 1.2 × 10-2 0.2 5.0 × 10-2 0.4 1.2 × 10-3 0.4 3.5 × 10-3 362912 Derl1 Der1-like domain family, member 1
0.6 6.6 × 10-2 0.3 2.3 × 10-2 0.6 1.7 × 10-3 0.6 6.5 × 10-4 691956 Derl2 Der1-like domain family, member 2
-0.4 1.5 × 10-1 -0.3 1.0 × 10-1 -0.4 5.9 × 10-3 -0.5 9.7 × 10-3 25313 Egf epidermal growth factor
0.3 6.3 × 10-1 1.1 2.0 × 10-1 1.2 3.3 × 10-4 0.6 9.8 × 10-3 171402 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast)
-0.3 2.9 × 10-1 -0.3 7.2 × 10-2 -0.7 1.0 × 10-3 -0.5 9.4 × 10-3 29580 Fdft1 farnesyl diphosphate farnesyl transferase 1
-0.3 3.7 × 10-1 -0.3 4.3 × 10-2 -0.7 4.2 × 10-4 -0.4 4.1 × 10-3 297029 Gstk1 glutathione S-transferase kappa 1
-0.5 9.3 × 10-2 -0.2 1.8 × 10-1 -0.7 6.9 × 10-3 -0.4 3.0 × 10-3 81869 Gstm7 glutathione S-transferase, mu 7
-1.3 7.2 × 10-3 -1.0 1.1 × 10-3 -1.1 3.4 × 10-2 -1.2 1.2 × 10-2 85255 Hacl1 2-hydroxyacyl-CoA lyase 1
-0.2 6.3 × 10-1 -0.3 1.8 × 10-1 -0.7 6.5 × 10-4 -0.7 2.2 × 10-3 24439 Hagh hydroxyacyl glutathione hydrolase
-0.6 2.5 × 10-2 -0.2 2.1 × 10-1 -0.6 2.7 × 10-3 -0.7 4.7 × 10-3 25116 Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1
0.5 1.5 × 10-1 0.3 1.1 × 10-1 0.9 1.0 × 10-3 0.6 4.8 × 10-3 84013 Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12
1.4 5.1 × 10-3 0.5 3.9 × 10-3 0.7 4.3 × 10-2 0.9 1.5 × 10-2 25663 Il1r1 interleukin 1 receptor, type I
-0.6 3.7 × 10-2 -0.3 1.8 × 10-1 -0.7 3.8 × 10-3 -0.8 6.1 × 10-4 690745 LOC690745 MOCO sulphurase C-terminal domain containing-like
0.2 8.5 × 10-1 -0.5 4.2 × 10-2 -0.8 8.5 × 10-4 -0.5 4.8 × 10-3 497794 Mug1 murinoglobulin 1
-0.4 8.6 × 10-2 -0.4 4.1 × 10-2 -0.6 3.6 × 10-3 -0.6 8.6 × 10-3 29227 Nfib nuclear factor I/B
-0.5 9.3 × 10-2 -0.6 3.2 × 10-2 -1.2 1.0 × 10-3 -0.5 1.4 × 10-3 680451 Nrbp2 nuclear receptor binding protein 2
-0.2 6.1 × 10-1 -0.4 1.0 × 10-2 -0.6 2.5 × 10-4 -0.5 3.4 × 10-3 94267 Nudt4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
1.0 1.6 × 10-2 0.7 4.2 × 10-2 0.7 4.6 × 10-3 1.2 1.9 × 10-5 171564 Pbld phenazine biosynthesis-like protein domain containing
0.4 4.5 × 10-2 0.3 4.2 × 10-2 0.4 7.6 × 10-3 0.4 1.5 × 10-3 308061 Pdcd6 programmed cell death 6
0.7 5.1 × 10-3 0.7 2.0 × 10-4 0.4 1.1 × 10-1 0.7 1.3 × 10-2 114209 Phyh phytanoyl-CoA 2-hydroxylase
0.6 1.6 × 10-2 0.4 5.2 × 10-2 0.5 2.7 × 10-3 0.8 7.7 × 10-5 64390 Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1
-0.3 3.3 × 10-1 -0.4 7.0 × 10-2 -0.6 4.3 × 10-3 -0.5 2.9 × 10-3 315655 Rdx radixin
-0.2 1.2 × 10-1 -0.4 1.5 × 10-2 -0.6 5.0 × 10-3 -0.5 1.3 × 10-3 363160 RGD1311563 similar to Oligosaccharyl transferase 3 CG7748-PA
0.1 3.1 × 10-1 0.2 1.1 × 10-1 1.4 7.3 × 10-3 0.7 4.1 × 10-4 315611 Scn4b sodium channel, type IV, beta
-0.3 3.7 × 10-1 -0.6 2.9 × 10-2 -1.2 6.8 × 10-4 -0.9 5.1 × 10-3 25216 Sdc1 syndecan 1
0.4 8.4 × 10-2 0.4 2.3 × 10-2 0.5 4.3 × 10-3 0.6 7.9 × 10-3 680891 Sf3b5 splicing factor 3b, subunit 5
-0.2 5.9 × 10-1 -0.3 3.5 × 10-2 -0.5 2.5 × 10-4 -0.4 2.6 × 10-3 81536 Sgpp1 sphingosine-1-phosphate phosphatase 1
-0.8 2.1 × 10-2 -0.6 5.0 × 10-2 -0.7 4.2 × 10-4 -0.7 2.0 × 10-3 79111 Slc27a5 solute carrier family 27 (fatty acid transporter), member 5
0.6 2.1 × 10-2 0.4 1.7 × 10-2 0.5 4.4 × 10-3 0.7 3.7 × 10-4 500707 Tc2n tandem C2 domains, nuclear
0.2 4.4 × 10-1 0.3 5.0 × 10-2 0.3 7.0 × 10-3 0.5 3.0 × 10-3 367909 Tceal8 transcription elongation factor A (SII)-like 8
-0.2 3.7 × 10-1 -0.3 8.3 × 10-2 -0.5 3.3 × 10-3 -0.4 3.4 × 10-3 170907 Tpo1 developmentally regulated protein TPO1
0.7 2.2 × 10-2 0.3 7.4 × 10-2 0.6 7.5 × 10-3 0.6 4.1 × 10-3 362890 Tspan31 tetraspanin 31
-0.2 3.8 × 10-1 -0.1 7.8 × 10-1 -0.4 6.3 × 10-3 -0.4 3.4 × 10-3 362696 Ttc7 tetratricopeptide repeat domain 7
-0.1 7.8 × 10-1 -0.3 6.2 × 10-2 -0.5 5.4 × 10-3 -0.5 4.5 × 10-3 363869 Ubl3 ubiquitin-like 3
-0.9 1.5 × 10-1 -0.5 2.9 × 10-1 -0.9 1.5 × 10-4 -1.1 1.3 × 10-3 117522 Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
0.3 4.6 × 10-2 0.4 1.2 × 10-2 0.6 1.3 × 10-3 0.7 4.3 × 10-3 360389 Zfp422 zinc finger protein 422
  1. Transcriptional responses after 19 hours TCDD exposure in the four rat strains/lines were identified using Affymetrix RAE230A arrays followed by data pre-processing and statistical testing using linear models. Type-II genes were identified as those where both strains/lines in one collective showed statistically significant responses to TCDD (padjusted < 0.01) in the same direction, while both strains/lines in the other collective showed no response (padjusted > 0.01). For each strain/line, the fold-change (FC in log2 space) in mRNA levels between treated and control rats as well as the significance levels are presented. Genes are sorted alphabetically by gene symbol.