Table 1 A selection of upregulated genes in wildtype-infected cells compared to uninfected cells.
Gene | Function | Fold Induction |
|---|---|---|
Association with the inhibition of the extrinsic pathway of apoptosis | ||
   TNFAIP3 | aka A20; inhibits TNF-alpha-induced apoptosis by inhibiting caspase-8 cleavage | 9.3 |
   TNFRSF12A | functions, in part, through the NF-κB pathway to up-regulate BCL-XL and BCL-W expression for malignant cell survival | 5.1 |
   CSE1L | binds strongly to importin-alpha; highly expressed in tumor cell lines and may play a role in inhibiting TNF-mediated cell death | 3.1 |
   FAIM3 | Fas apoptotic inhibitory molecule 3; inhibits caspase-8 processing | 2.7 |
   BAG4 | associates with TNFR1 and death receptor-3 to negatively regulate downstream death signaling | 2.6 |
   CFLAR | CASP8 and FADD-like apoptosis regulator; aka c-FLIP; interacts with FADD and FLICE; inhibits apoptosis via human death receptors | 2.5 |
   FAIM | Fas apoptotic inhibitory molecule; pro-survival; mediates Fas resistance produced by surface Ig engagement in B cells | 2.1 |
   PEA15 | a death effector domain (DED)-containing protein; inhibits both TNFRSF6 and TNFRSF1A-mediated CASP8 activity & apoptosis | 2.1 |
   TNFAIP8 | tumor necrosis factor, alpha-induced protein 8; inhibits the activated form of caspase-8 | 2.1 |
Interaction with caspases (IAP genes) | ||
   BIRC4 | aka XIAP; inhibits apoptosis through binding to TRAF1 and TRAF2; also inhibits caspase-3 and caspase-7 | 3.5 |
   BIRC1 | aka NAIP; homology to two baculoviral IAPs; suppresses apoptosis induced by various signals; binds caspase-9 | 3.2 |
   BIRC5 | aka survivin; with hepatitis B X-interacting protein (HBXIP) binds caspase-9; variant DeltaEx3 binds caspase-3 with BCL-2 | 2.8 |
   BIRC7 | aka livin; shown to interact with caspase-3, -7, & -9; degrades Smac/DIABLO | 2.8 |