Table 2 A selection of upregulated genes in wildtype-infected cells with staurosporine compared to uninfected cells with staurosporine.
Gene | Function | Fold Induction |
|---|---|---|
Association with p53 | ||
   TP53BP2 | a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins | 3.3 |
   TP73L | aka tumor protein p63; homolog to p53 | 3.1 |
   JUND | member of the JUN family; a component of the AP1 TF complex; proposed to protect cells from p53-dependent senescence and apoptosis | 2.8 |
   P53AIP1 | P53-regulated apoptosis-inducing protein 1; p53AIP1 regulates the mitochondrial apoptotic pathway | 2.7 |
   CUL4A | functions as an E3 ligase & with MDM2, contributes to p53 degradation; assists in nucleotide excision repair in a complex with DDB | 2.6 |
   LRDD | interacts FADD & MADD; may function as an adaptor protein in cell death-related signaling processes; a p53 effector (induces apoptosis) | 2.5 |
   NEDD8 | similar to ubiquitin; conjugated to p53 via MDM2, thereby inhibiting the transcriptional activity of p53 | 2.2 |
   PPP2CA | the phosphatase 2A catalytic subunit; inhibits cell growth and activates p53 & p21 (p53-responsive); overexpression leads to G2/M arrest | 2.2 |
   MDM4 | contains a RING finger domain & a putative nuclear localization signal; interacts with p53 (stabilizes to counteract MDM2) | 2.0 |
Association with pRB | ||
   RBBP4 | involved in chromatin remodeling & transcriptional repression associated with histone deacetylation; binds directly to pRB | 3.7 |
   JARID1A | aka RBBP2; binds with pRB for tumor suppressive functions; may interact with rhombotin-2 | 2.7 |
   RBBP5 | a ubiquitously expressed nuclear protein; binds pRB, which regulates cell proliferation | 2.3 |
   RBBP6 | binds to unphosphorylated but not phosphorylated pRB; also binds p53; blocks suppression of adenoviral E1A protein | 2.0 |