Skip to main content

Advertisement

Table 2 A selection of upregulated genes in wildtype-infected cells with staurosporine compared to uninfected cells with staurosporine.

From: Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition

Gene Function Fold Induction
Association with p53
   TP53BP2 a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins 3.3
   TP73L aka tumor protein p63; homolog to p53 3.1
   JUND member of the JUN family; a component of the AP1 TF complex; proposed to protect cells from p53-dependent senescence and apoptosis 2.8
   P53AIP1 P53-regulated apoptosis-inducing protein 1; p53AIP1 regulates the mitochondrial apoptotic pathway 2.7
   CUL4A functions as an E3 ligase & with MDM2, contributes to p53 degradation; assists in nucleotide excision repair in a complex with DDB 2.6
   LRDD interacts FADD & MADD; may function as an adaptor protein in cell death-related signaling processes; a p53 effector (induces apoptosis) 2.5
   NEDD8 similar to ubiquitin; conjugated to p53 via MDM2, thereby inhibiting the transcriptional activity of p53 2.2
   PPP2CA the phosphatase 2A catalytic subunit; inhibits cell growth and activates p53 & p21 (p53-responsive); overexpression leads to G2/M arrest 2.2
   MDM4 contains a RING finger domain & a putative nuclear localization signal; interacts with p53 (stabilizes to counteract MDM2) 2.0
Association with pRB
   RBBP4 involved in chromatin remodeling & transcriptional repression associated with histone deacetylation; binds directly to pRB 3.7
   JARID1A aka RBBP2; binds with pRB for tumor suppressive functions; may interact with rhombotin-2 2.7
   RBBP5 a ubiquitously expressed nuclear protein; binds pRB, which regulates cell proliferation 2.3
   RBBP6 binds to unphosphorylated but not phosphorylated pRB; also binds p53; blocks suppression of adenoviral E1A protein 2.0