Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major

Table 1 Estimation of the numbers of conventional CCCH motifs in protozoa and yeast.

Organism	No of CCCH motifs (unfiltered) Y/Z (C-X_Y-C-X_Z-C-X₃-H)				Genome			Total number of CCCH motifs (background corrected)
	7/5	8/5	7/7	8/7	Size (Mbp)	No of genes	Ref.
T. brucei	37	28	4	2	26.1	9068	[59]	59
L. major	31	31	5	6	32.8	8272	[17]	51
T. cruzi	62	59	3	8	60.4	22570	[60]	110
T. annulata	7	6	0	1	8.4	3792	[61]	12
D. discoideum	18	18	4	2	33.9	12500	[62]	30
P. falciparum	24	9	2	5	22.9	5268	[63]	26
T. gondii GT1	36	19	5	1	63.0	8155	[64]; ToxoDB	49
S. pombe	12	9	2	2	12.5	5027	[65]	17
S. cerevisiae	7	6	1	0	12.1	5885	[66]	12

The genomes of the organisms listed were searched for the two conventional CCCH motifs and in addition for two fantasy CCCH motifs (C-X₇-C-X₇-C-X₃-H and C-X₈-C-X₇-C-X₃-H). No filtering steps were performed. The total number of conventional CCCH motifs was estimated by adding the numbers of the two conventional CCCH motifs and subtracting the numbers of the two fantasy CCCH motifs.

ISSN: 1471-2164