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Table 3 Top ten genes found differentially up- or down-regulated after LPS or PMA/ionomycin stimulation

From: Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response

  LPS stimulation PMA/ionomycin stimulation
  Genes Clusters2 Fold change Genes Clusters2 Fold change
Up-regulation SAA1 C4 26.84 IL2 No3 9.96
  IL8 C3 23.96 HSP90AB1 C6 8.49
  CCL2 C4 13.36 NPM1 C6 8.21
  S100A9 C3 13.33 CD69 No3 6.87
  CXCL5 C4 12.42 TNFRSF9 No3 6.62
  S100A12 No3 10.92 NPM3 C6 6.61
  CXCL3 No3 9.55 HSPD1 C6 6.51
  CXCL2 No3 7.96 GAPDH C6 6.20
  CCL8 No3 7.36 RPS2 C6 5.31
  SOD2 C6 5.85 RAN C6 5.31
Down-regulation LYZ1 C1 -8.59 THBS1 C2 -65.98
  FN11 C1 -7.57 FOLR11 C1 -19.74
  SLA-DRB1 C8 -3.23 LYZ1 C1 -14.76
  FOLR11 C1 -3.21 FN11 C1 -12.26
  CST31 C8 -2.80 CSF1R C8 -8.15
  SLA-DQB1 C8 -2.74 TGFBI C8 -6.78
  SLA-DOB C8 -2.69 CST31 C8 -6.51
  CST21 C8 -2.67 CST21 C8 -5.80
  SLA-DRA C8 -2.65 CD163 No3 -5.59
  SLA-DQA1 C8 -2.40 CTSZ C8 -5.58
  1. 1 Genes that are commonly down-regulated after LPS or PMA/ionomycin stimulation
  2. 2 The clusters refer to the hierarchical clustering reported in Figure 2 and Additional file 4
  3. 3 "No" means that the genes were found differentially expressed in only one stimulation condition and were not included in the hierarchical clustering.