TY - JOUR AU - Jumbo-Lucioni, Patricia AU - Ayroles, Julien F. AU - Chambers, Michelle Moses AU - Jordan, Katherine W. AU - Leips, Jeff AU - Mackay, Trudy FC AU - De Luca, Maria PY - 2010 DA - 2010/05/11 TI - Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster JO - BMC Genomics SP - 297 VL - 11 IS - 1 AB - Obesity and phenotypic traits associated with this condition exhibit significant heritability in natural populations of most organisms. While a number of genes and genetic pathways have been implicated to play a role in obesity associated traits, the genetic architecture that underlies the natural variation in these traits is largely unknown. Here, we used 40 wild-derived inbred lines of Drosophila melanogaster to quantify genetic variation in body weight, the content of three major metabolites (glycogen, triacylglycerol, and glycerol) associated with obesity, and metabolic rate in young flies. We chose these lines because they were previously screened for variation in whole-genome transcript abundance and in several adult life-history traits, including longevity, resistance to starvation stress, chill-coma recovery, mating behavior, and competitive fitness. This enabled us not only to identify candidate genes and transcriptional networks that might explain variation for energy metabolism traits, but also to investigate the genetic interrelationships among energy metabolism, behavioral, and life-history traits that have evolved in natural populations. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-11-297 DO - 10.1186/1471-2164-11-297 ID - Jumbo-Lucioni2010 ER -