Figure 2

Two representative examples of aCGH, MLPA and MAQ NB tumor profiles A. NB cell line SJNB-10 with segmental aberrations, including 1p deletion, MYCN amplification, 3p deletion, 17q gain. B. NB tumor with numerical aberrations including whole chromosome 1, 2 and 17 gain, and whole chromosome 3 and 11 loss. Gray = normal; Red = loss; Green = gain (according to scoring thresholds). Horizontal bars in array profiles indicate CBS values. Red and green cross marks point at CBS values above or below 0.3 or -0.3, respectively. In Figure 2B all crosses indicate known copy number variations. Error bars of each dosage quotient (DQ) are based on the standard deviation after summarizing the DQ values using different reference amplicons and 3 (MLPA) or 2 (MAQ) control samples.