Table 1 Performance of MLPA and MAQ
| Â | Chromosome 1p | MYCN status | Chromosome 3p | Chromosome 11q | Chromosome 17q | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Segmental (n = 35) | MLPA | MAQ | MLPA | MAQ | MLPA | MAQ | MLPA | MAQ | MLPA | MAQ |
AUC | 94.4% | 97.1% | 100.0% | 100.0% | 94.3% | 100.0% | 97.1% | 97.1% | 100.0% | 100.0% |
Sensitivity | 100.0% | 94.4% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
Specificity | 88.9% | 100.0% | 100.0% | 100.0% | 92.0% | 100.0% | 95.5% | 95.5% | 100.0% | 100.0% |
PPV | 90.0% | 100.0% | 100.0% | 100.0% | 83.3% | 100.0% | 92.9% | 92.9% | 100.0% | 100.0% |
NPV | 100.0% | 94.4% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
| Â | 95% Confidence Interval AUC(MLPA): 94%-100% | 95% Confidence Interval AUC(MAQ): 97%-100% | ||||||||
| Â | Chromosome 1 | Chromosome 2 | Chromosome 3 | Chromosome 11 | Chromosome 17 | |||||
Numerical (n = 17) | MLPA | MAQ | MLPA | MAQ | MLPA | MAQ | MLPA | MAQ | MLPA | MAQ |
AUC | 76.5% | 88.2% | 92.3% | 76.9% | 58.8% | 76.5% | 70.6% | 76.5% | 94.1% | 94.1% |
Sensitivity | 77.8% | 77.8% | 90.0% | 70.0% | 46.2% | 69.2% | 71.4% | 71.4% | 94.1% | 94.1% |
Specificity | 75.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 66.7% | 100.0% | 100.0% | 100.0% |
PPV | 77.8% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 90.9% | 100.0% | 100.0% | 100.0% |
NPV | 75.0% | 80.0% | 75.0% | 50.0% | 36.4% | 50.0% | 33.3% | 42.9% | 100.0% | 100.0% |
| Â | 95% Confidence Interval AUC(MLPA): 60%-97% | 95% Confidence Interval AUC(MAQ): 72%-93% | ||||||||