Figure 3

The nucleotide sequences of the TRBC isotypes derived from the cDNA clones. Only the 14 variable nucleotide codons (12 in the first and two in the third exons numbered from the first position of the constant region in the cDNA) are depicted. The amino acids specified by the corresponding codons and those due to the nucleotide substitutions are given at the top of each codon, using the single letter code. The sequences are organized with respect to the one allelic TRBC3 sequence isolated from Moscia Leccese breed young thymus. Identities of the other allelic form of the same gene or of the other TRBC isotypes in the other tissues with respect to the reference sequence are indicated by dashes, while nucleotide substitutions are shown. The number on the left indicates the clones with the corresponding sequences. All the allelic forms of the TRBC isotypes are identified by a color. Color changes indicate recombinational diversification or alternative splicing.