Figure 1

Linkage disequilibrium analysis of the β-thalassemia sample. Distribution of linkage disequilibrium between each of polymorphic sites and the β-thalassemia causing mutation in a 20.693 kb region surrounding the human β -globin gene. (a) Estimates of the coefficients of LD from three different methods. The dot lines represent the lowest and highest theoretical bounds of the disequilibrium parameter, which are defined by allele frequencies at the polymorphic marker and disease causing sites. (b) The LOD score values calculated for the LD estimates from the three methods.