Figure 5

Cytokine and growth factor enrichment in mammary parenchyma. Interaction of cytokines and growth factors highly expressed in parenchyma (PAR) relative to mammary fat pad (MFP) with DEG highly expressed in MFP vs. PAR. Objects for cytokines and growth factors largely expressed in PAR vs. MFP are denoted by blue-filled objects. Objects for DEG largely expressed in MFP vs. PAR are depicted in shades of orange. The intensity of the color relates to the fold difference in PAR vs. MFP (blues) of MFP vs. PAR (orange). Molecule types have their background highlighted as follows: enzymes, yellow; cytokines and growth factors potentially secreted by PAR, red; cytokines and growth factors highly-expressed in MFP vs. PAR, green; membrane and G-coupled receptors, black (white font); phosphatase and kinases, gray; transcription factors and nuclear-dependent transcription regulators, dark-pink. All other molecules have white background. The intensity of the shaded color in the object relates to the fold-difference in MFP vs. PAR (orange) or PAR vs. MFP (blue). Red arrows denote effects on gene expression, purple arrows denote activation, dark-violet arrows denote phosphorylation, and green arrows denote protein-protein interactions. Arrow edges are expression (E), activation (A), modification (m), protein-protein interaction (PP), protein-RNA interaction (PR), phosphorylation (P), and translocation (TR). Legend for the shape of the objects is reported in the figure.