Table 5 Parenchyma and fat pad cytokines and growth factors among DEG between tissues (1.5-fold difference in mRNA abundance).

DEG highly-expressed in parenchyma vs. fat pad

   SPP1

secreted phosphoprotein 1 (osteopontin)

Protein binding

Cyt

22.1

   CXCL10

chemokine (C-X-C motif) ligand 10

Chemokine activity, chemotaxis

Cyt

3.5

   PDGFA

platelet-derived growth factor alpha polypeptide

Actin cytoskeleton organization

GrF

2.2

   DKK1

dickkopf homolog 1 (Xenopus laevis)

Inhibition of Wnt signaling

GrF

2.1

   NRG1

neuregulin 1

Cell-cell communication, murine mammary development

GrF

2.0

   BDNF

brain-derived neurotrophic factor

Anti-apoptosis, axon guidance

GrF

1.8

   NTF4

neurotrophin 4

Regulation of synaptic plasticity

GrF

1.7

   ANGPT1

angiopoietin 1

Angiogenesis, signal transduction

GrF

1.6

   IL7

interleukin 7

Anti-apoptosis, cell-cell signalling

Cyt

1.6

   FGF7

fibroblast growth factor 7 (keratinocyte growth factor)

Positive regulation of epithelial cell proliferation, signal transduction

GrF

1.6

   LTA

lymphotoxin alpha (TNF superfamily, member 1)

TNF receptor binding, immune response

Cyt

1.6

   IL1B

interleukin 1, beta

Immune response, chemotaxis, anti/pro-apoptosis

Cyt

1.6

   CCL2

chemokine (C-C motif) ligand 2

Chemotaxis, immune response, endothelial cell proliferation

Cyt

1.5

   CXCL14

chemokine (C-X-C motif) ligand 14

Chemotaxis, immune response

Cyt

4.4

   CXCL9

chemokine (C-X-C motif) ligand 9

Chemotaxis, immune response

Cyt

2.3

   VAV3

vav 3 guanine nucleotide exchange factor

Metal ion binding, protein binding

Cyt

2.2

   HDGF

hepatoma-derived growth factor

Cell proliferation, regulation of transcription, DNA-dependent

GrF

1.9

   CXCL6

chemokine (C-X-C motif) ligand 6

Chemotaxis, immune response

Cyt

1.9

   MDK

midkine (neurite growth-promoting factor 2)

Cell differentiation/proliferation, nervous system development

GrF

1.7

DEG highly-expressed in fat pad vs. parenchyma

   ADIPOQ

adiponectin, C1Q and collagen domain containing

Negative regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of inflammation

GrF

24.1

   FGF2

fibroblast growth factor 2 (basic)

Chemotaxis, positive regulation of angiogenesis and epithelial cell proliferation

GrF

3.5

   GRP

gastrin-releasing peptide

Signal transduction, hormone activity, neuropeptide signaling

GrF

2.9

   NOV

nephroblastoma overexpressed gene

Insulin-like growth factor binding, regulation of cell growth

GrF

2.5

   FGF8

fibroblast growth factor 8 (androgen-induced)

Cell proliferation, signal transduction, induced by androgens in breast cancer cells

GrF

1.9

   LEP

Leptin

Hormone activity, regulation of metabolic process

GrF

1.9

   IL13

interleukin 13

Cell motion, cell-cell signaling, immune response

Cyt

1.7

   JAG1

jagged 1 (Alagille syndrome)

Angiogenesis, cell fate determination, regulation of cell proliferation, activation of Notch signaling pathway

GrF

1.6

   IL1A

interleukin 1, alpha

Immune response, positive regulation of cytokine secretion, pro-angiogenesis

Cyt

1.6

   CCL14

chemokine (C-C motif) ligand 14

Cellular calcium homeostasis, immune response, positive regulation of cell proliferation

Cyt

1.9

   OGN

Osteoglycin

Protein binding

GrF

1.8

   EDA

ectodysplasin A

Cell differentiation, immune response, positive regulation of NF-kappaB transcription

Cyt

1.7

   CCL24

chemokine (C-C motif) ligand 24

Chemotaxis, immune response, cell-cell signaling

Cyt

1.7

   CXCL2

chemokine (C-X-C motif) ligand 2

Chemotaxis, immune response

Cyt

1.6

   CCL20

chemokine (C-C motif) ligand 20

Chemotaxis, immune response, cell-cell signalling

Cyt

1.5