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Table 5 Parenchyma and fat pad cytokines and growth factors among DEG between tissues (1.5-fold difference in mRNA abundance).

From: Functional and gene network analyses of transcriptional signatures characterizing pre-weaned bovine mammary parenchyma or fat pad uncovered novel inter-tissue signaling networks during development

Name Description Biological functions/process1 Type2 FD3
DEG highly-expressed in parenchyma vs. fat pad
   SPP1 secreted phosphoprotein 1 (osteopontin) Protein binding Cyt 22.1
   CXCL10 chemokine (C-X-C motif) ligand 10 Chemokine activity, chemotaxis Cyt 3.5
   PDGFA platelet-derived growth factor alpha polypeptide Actin cytoskeleton organization GrF 2.2
   DKK1 dickkopf homolog 1 (Xenopus laevis) Inhibition of Wnt signaling GrF 2.1
   NRG1 neuregulin 1 Cell-cell communication, murine mammary development GrF 2.0
   BDNF brain-derived neurotrophic factor Anti-apoptosis, axon guidance GrF 1.8
   NTF4 neurotrophin 4 Regulation of synaptic plasticity GrF 1.7
   ANGPT1 angiopoietin 1 Angiogenesis, signal transduction GrF 1.6
   IL7 interleukin 7 Anti-apoptosis, cell-cell signalling Cyt 1.6
   FGF7 fibroblast growth factor 7 (keratinocyte growth factor) Positive regulation of epithelial cell proliferation, signal transduction GrF 1.6
   LTA lymphotoxin alpha (TNF superfamily, member 1) TNF receptor binding, immune response Cyt 1.6
   IL1B interleukin 1, beta Immune response, chemotaxis, anti/pro-apoptosis Cyt 1.6
   CCL2 chemokine (C-C motif) ligand 2 Chemotaxis, immune response, endothelial cell proliferation Cyt 1.5
   CXCL14 chemokine (C-X-C motif) ligand 14 Chemotaxis, immune response Cyt 4.4
   CXCL9 chemokine (C-X-C motif) ligand 9 Chemotaxis, immune response Cyt 2.3
   VAV3 vav 3 guanine nucleotide exchange factor Metal ion binding, protein binding Cyt 2.2
   HDGF hepatoma-derived growth factor Cell proliferation, regulation of transcription, DNA-dependent GrF 1.9
   CXCL6 chemokine (C-X-C motif) ligand 6 Chemotaxis, immune response Cyt 1.9
   MDK midkine (neurite growth-promoting factor 2) Cell differentiation/proliferation, nervous system development GrF 1.7
DEG highly-expressed in fat pad vs. parenchyma
   ADIPOQ adiponectin, C1Q and collagen domain containing Negative regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of inflammation GrF 24.1
   FGF2 fibroblast growth factor 2 (basic) Chemotaxis, positive regulation of angiogenesis and epithelial cell proliferation GrF 3.5
   GRP gastrin-releasing peptide Signal transduction, hormone activity, neuropeptide signaling GrF 2.9
   NOV nephroblastoma overexpressed gene Insulin-like growth factor binding, regulation of cell growth GrF 2.5
   FGF8 fibroblast growth factor 8 (androgen-induced) Cell proliferation, signal transduction, induced by androgens in breast cancer cells GrF 1.9
   LEP Leptin Hormone activity, regulation of metabolic process GrF 1.9
   IL13 interleukin 13 Cell motion, cell-cell signaling, immune response Cyt 1.7
   JAG1 jagged 1 (Alagille syndrome) Angiogenesis, cell fate determination, regulation of cell proliferation, activation of Notch signaling pathway GrF 1.6
   IL1A interleukin 1, alpha Immune response, positive regulation of cytokine secretion, pro-angiogenesis Cyt 1.6
   CCL14 chemokine (C-C motif) ligand 14 Cellular calcium homeostasis, immune response, positive regulation of cell proliferation Cyt 1.9
   OGN Osteoglycin Protein binding GrF 1.8
   EDA ectodysplasin A Cell differentiation, immune response, positive regulation of NF-kappaB transcription Cyt 1.7
   CCL24 chemokine (C-C motif) ligand 24 Chemotaxis, immune response, cell-cell signaling Cyt 1.7
   CXCL2 chemokine (C-X-C motif) ligand 2 Chemotaxis, immune response Cyt 1.6
   CCL20 chemokine (C-C motif) ligand 20 Chemotaxis, immune response, cell-cell signalling Cyt 1.5
  1. Reported in bold font are cytokines and growth factors differentially expressed in one of the two tissues which can potentially interact with highly-expressed DEG in the other tissue as shown in networks reported in Figure 5 and 6.
  2. 1 NCBI GO annotation
  3. 2 Cytokines (Cyt) and growth factor (GrF)
  4. 2 Fold difference (FD) in gene expression between tissues