Potential interactions observed by in silico and yeast two hybrid approach between the GTF and ApiAP2. TAP candidates eliciting interactions from in silico  and Y2D data  were extracted from PlasmoDB and only the proteins for which an interaction was inferred are presented. The two networks were merged and graphically represented using Cytoscape 2.6 http://www.cytoscape.org. Red circle stands for general transcription factors, yellow for chromatin-related proteins, green for specific transcription factors and blue for partners. Grey lines represent the in silico interactions and pink lines those proposed by the two-hybrid experiment. A. Interaction network for the preinitiation complexe. B. Interaction network for the ApiAP2 TF. For the complete interaction network see Additional file 5.