Table 3 Top functions and disorders predicted by IPA to be affected by dystrophin deficiency
Function or Disorder | Molecules | Adjusted p value |
|---|---|---|
contraction of muscle | ACTN3, CASQ1, CHRNE, CKMT2, EGF, GJA5, HSPB6, KCNMA1, MYBPC1, MYBPC2, MYBPC3, MYH1, MYH7, MYLK2, TMOD4 | 6.33E-04 |
atrophy of muscle cells | ACHE, FBXO32, PPARGC1A | 1.27E-02 |
skeletal and muscular disorder | ACHE, ACTN3, AIG1, ALKBH8, ARPP-21, BAALC, BLNK, CACNA2D1, CAMK2B, CAMTA1, CAPN3, CASQ1, CDC42BPA, CDH13, CDKN1A, CENPM, CFL2, CHRNE, CLIP4, COL23A1, CYFIP2, DCLK3, DMD, DNAJB6, GABRD, GAN, GIGYF2, GPD1, HTR2B, IL12A, IMPA2, IP6K3, KCNC1, KCNMA1, KCNN3, LDB3, LPIN1, MAOB, MLF1, MLLT3, MYBPC1, MYH7, MYH8, MYT1L, NDRG2, NOG, PADI2, PFKM, PKD1L1, PPARGC1A, PVALB, RCSD1, SCN1B, SCN3B, SERPINB1, SGCG, SORT1, SPTB, STARD10, TBC1D4, TCAP, TNRC6B, TP53BP1, TPM3, UCK2, WBSCR17, WFDC1, XK | 1.46E-02 |
cardiovascular disorder | ABI2, ACHE, ACTN3, ARHGAP20, BLNK, CACNA2D1, CAMK2B, CAMTA1, CDC42BPA, CDH13, CDKN1A, CHRNA10, CHRNE, COL23A1, CSRNP3, CYFIP2, DMD, ENTPD3, FAM65B, GABRD, GAN, GJA5, GRHL1, HERC1, HSD11B1, HTR2B, IL12A, IMPA2, KCNA7, KCNC1, KCNK3, KCNMA1, KCNN3, KIAA1409, MALL (includes EG:7851), MAOB, MLF1, MSI2, MYBPC1, MYBPC3, MYH7, MYH8, MYLK2, NPPB, PPARGC1A, PSTPIP2, PTPRO, RCSD1, SCN1B, SGCG, SLC46A3, SLC9A2, SPTB, TBC1D4, TCAP, TNRC6B, WBSCR17, XK | 2.07E-02 |
cardiomyopathy | GJA5, HTR2B, MYBPC3, MYH7, MYLK2, NPPB, PPARGC1A, SGCG, TCAP | 2.07E-02 |
variant angina | CACNA2D1, RCSD1, SGCG | 2.07E-02 |
Huntington's disease | ACTN3, AIG1, ARPP-21, CAMK2B, CASQ1, CYFIP2 (includes EG:26999), GABRD, GPD1, KCNN3, MAOB, MLF1, MYH7, MYT1L, PFKM, PPARGC1A, PVALB, SCN1B, SCN3B, SORT1, STARD10, TPM3, UCK2 | 3.09E-02 |
disease of muscle | CHRNE, FBXO32, MYH1, MYH4, PPARGC1A, SGCG, TPM3 | 4.23E-02 |
fatigue | ACHE, CHRNE, PPARGC1A, SCN1B | 4.23E-02 |
developmental disorder of muscle | FBXO32, MYH1, MYH4, SGCG, TPM3 | 4.39E-02 |
pervasive developmental disorders | ACHE, CHRNA10, CHRNE, GABRD, HTR2B, SCN1B, SCN3B | 4.39E-02 |
deformation of nucleus | CDKN1A, MAP7 | 4.39E-02 |
metabolism of carbohydrate | CMAH, GPD1, IMPA2, IP6K3, NISCH, PDK4, PFKM, PHKG1, PPARGC1A, PPP1R3C, PYGM, SGSH, SOCS4, ST3GAL6 | 4.39E-02 |
morphogenesis of cardiac muscle | MYBPC3, MYH7, MYLK2, TCAP | 4.63E-02 |
muscular dystrophy | CAPN3, DMD, MYH7, SGCG, TCAP | 4.69E-02 |
neurological disorder | ACHE, ACTN3, AIG1, ALKBH8, ARPP-21, BAALC, BLNK, CACNA2D1, CAMK2B, CAMTA1, CAPN3, CASQ1, CATSPER4, CDC42BPA, CDH13, CHRNA10, CHRNE, CLIP4, CNKSR1, COL23A1, CYFIP2, DFNA5, DMD, DNAJB6, DNAJC5, EGF, EYA3, FZD3, GABRD, GAN, GDAP1, GIGYF2, GPD1, HTR2B, IGFN1, IL12A, IMPA2, KCNC1, KCNMA1, KCNN3, KIAA1409, KPNA6, LRCH1, MAOB, MLF1, MLLT3, MSI2, MT3, MYH7, MYH8, MYT1L, NDRG2, OPN3, P2RY2, PADI2, PFKM, PKD1L1, PLA2G4E, PPARGC1A, PPP1R14C, PVALB, SCN1B, SCN3B, SERPINB1, SGCG, SORT1, SPTB, STARD10, SUSD4, TMEM108, TPM3, TTC7B, TTLL7, UCK2, WBSCR17, WWC1, XK | 4.80E-02 |
developmental process of muscle | ACHE, CAPN3, CDKN1A, DMD, KY, MYBPC3, MYH7, MYLK2, MYOZ1, PDK4, SGCG, TCAP | 4.80E-02 |