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Table 3 Top functions and disorders predicted by IPA to be affected by dystrophin deficiency

From: Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization

Function or Disorder Molecules Adjusted p value
contraction of muscle ACTN3, CASQ1, CHRNE, CKMT2, EGF, GJA5, HSPB6, KCNMA1, MYBPC1, MYBPC2, MYBPC3, MYH1, MYH7, MYLK2, TMOD4 6.33E-04
atrophy of muscle cells ACHE, FBXO32, PPARGC1A 1.27E-02
skeletal and muscular disorder ACHE, ACTN3, AIG1, ALKBH8, ARPP-21, BAALC, BLNK, CACNA2D1, CAMK2B, CAMTA1, CAPN3, CASQ1, CDC42BPA, CDH13, CDKN1A, CENPM, CFL2, CHRNE, CLIP4, COL23A1, CYFIP2, DCLK3, DMD, DNAJB6, GABRD, GAN, GIGYF2, GPD1, HTR2B, IL12A, IMPA2, IP6K3, KCNC1, KCNMA1, KCNN3, LDB3, LPIN1, MAOB, MLF1, MLLT3, MYBPC1, MYH7, MYH8, MYT1L, NDRG2, NOG, PADI2, PFKM, PKD1L1, PPARGC1A, PVALB, RCSD1, SCN1B, SCN3B, SERPINB1, SGCG, SORT1, SPTB, STARD10, TBC1D4, TCAP, TNRC6B, TP53BP1, TPM3, UCK2, WBSCR17, WFDC1, XK 1.46E-02
cardiovascular disorder ABI2, ACHE, ACTN3, ARHGAP20, BLNK, CACNA2D1, CAMK2B, CAMTA1, CDC42BPA, CDH13, CDKN1A, CHRNA10, CHRNE, COL23A1, CSRNP3, CYFIP2, DMD, ENTPD3, FAM65B, GABRD, GAN, GJA5, GRHL1, HERC1, HSD11B1, HTR2B, IL12A, IMPA2, KCNA7, KCNC1, KCNK3, KCNMA1, KCNN3, KIAA1409, MALL (includes EG:7851), MAOB, MLF1, MSI2, MYBPC1, MYBPC3, MYH7, MYH8, MYLK2, NPPB, PPARGC1A, PSTPIP2, PTPRO, RCSD1, SCN1B, SGCG, SLC46A3, SLC9A2, SPTB, TBC1D4, TCAP, TNRC6B, WBSCR17, XK 2.07E-02
cardiomyopathy GJA5, HTR2B, MYBPC3, MYH7, MYLK2, NPPB, PPARGC1A, SGCG, TCAP 2.07E-02
variant angina CACNA2D1, RCSD1, SGCG 2.07E-02
Huntington's disease ACTN3, AIG1, ARPP-21, CAMK2B, CASQ1, CYFIP2 (includes EG:26999), GABRD, GPD1, KCNN3, MAOB, MLF1, MYH7, MYT1L, PFKM, PPARGC1A, PVALB, SCN1B, SCN3B, SORT1, STARD10, TPM3, UCK2 3.09E-02
disease of muscle CHRNE, FBXO32, MYH1, MYH4, PPARGC1A, SGCG, TPM3 4.23E-02
fatigue ACHE, CHRNE, PPARGC1A, SCN1B 4.23E-02
developmental disorder of muscle FBXO32, MYH1, MYH4, SGCG, TPM3 4.39E-02
pervasive developmental disorders ACHE, CHRNA10, CHRNE, GABRD, HTR2B, SCN1B, SCN3B 4.39E-02
deformation of nucleus CDKN1A, MAP7 4.39E-02
metabolism of carbohydrate CMAH, GPD1, IMPA2, IP6K3, NISCH, PDK4, PFKM, PHKG1, PPARGC1A, PPP1R3C, PYGM, SGSH, SOCS4, ST3GAL6 4.39E-02
morphogenesis of cardiac muscle MYBPC3, MYH7, MYLK2, TCAP 4.63E-02
muscular dystrophy CAPN3, DMD, MYH7, SGCG, TCAP 4.69E-02
neurological disorder ACHE, ACTN3, AIG1, ALKBH8, ARPP-21, BAALC, BLNK, CACNA2D1, CAMK2B, CAMTA1, CAPN3, CASQ1, CATSPER4, CDC42BPA, CDH13, CHRNA10, CHRNE, CLIP4, CNKSR1, COL23A1, CYFIP2, DFNA5, DMD, DNAJB6, DNAJC5, EGF, EYA3, FZD3, GABRD, GAN, GDAP1, GIGYF2, GPD1, HTR2B, IGFN1, IL12A, IMPA2, KCNC1, KCNMA1, KCNN3, KIAA1409, KPNA6, LRCH1, MAOB, MLF1, MLLT3, MSI2, MT3, MYH7, MYH8, MYT1L, NDRG2, OPN3, P2RY2, PADI2, PFKM, PKD1L1, PLA2G4E, PPARGC1A, PPP1R14C, PVALB, SCN1B, SCN3B, SERPINB1, SGCG, SORT1, SPTB, STARD10, SUSD4, TMEM108, TPM3, TTC7B, TTLL7, UCK2, WBSCR17, WWC1, XK 4.80E-02
developmental process of muscle ACHE, CAPN3, CDKN1A, DMD, KY, MYBPC3, MYH7, MYLK2, MYOZ1, PDK4, SGCG, TCAP 4.80E-02
  1. Genes listed in the Additional file 2 were used for this analysis. Only functions and disorders with Benjamini-Hochberg corrected p values < 0.05 are displayed.
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BMC Genomics

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