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Table 1 Identification of TFAP2A binding sites in the core promoter of candidate TFAP2A-modulated genes.

From: Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

Minimum number of binding sites per gene

TFA2A binding site score threshold

Genome-wide

TFAP2A-regulated genes

p (Fisher test)

1

All sites

19402

468

 
 

best 30% (≥11.02)

14710

401

7.03E-08

 

best 20% (≥11.44)

12686

363

4.56E-09

 

best 10% (≥12.14)

9416

283

1.02E-07

2

All sites

17540

447

 
 

best 30% (≥11.02)

10959

322

1.03E-05

 

best 20% (≥11.44)

8636

264

1.53E-05

 

best 10% (≥12.14)

4955

155

2.0E-03

  1. Number of genome-wide or candidate TFAP2A-modulated human protein-coding genes containing at least one or two high score TFAP2A binding sites defined at various score thresholds (10%, 20%, 30%) in their core promoters. By considering only high-scoring sites we obtained a significant enrichment in TFAP2A-modulated genes compared with total binding sites, as shown by the p-values in the last column (exact Fisher Test).
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BMC Genomics

ISSN: 1471-2164

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