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Table 1 Identification of TFAP2A binding sites in the core promoter of candidate TFAP2A-modulated genes.

From: Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

Minimum number of binding sites per gene TFA2A binding site score threshold Genome-wide TFAP2A-regulated genes p (Fisher test)
1 All sites 19402 468  
  best 30% (≥11.02) 14710 401 7.03E-08
  best 20% (≥11.44) 12686 363 4.56E-09
  best 10% (≥12.14) 9416 283 1.02E-07
2 All sites 17540 447  
  best 30% (≥11.02) 10959 322 1.03E-05
  best 20% (≥11.44) 8636 264 1.53E-05
  best 10% (≥12.14) 4955 155 2.0E-03
  1. Number of genome-wide or candidate TFAP2A-modulated human protein-coding genes containing at least one or two high score TFAP2A binding sites defined at various score thresholds (10%, 20%, 30%) in their core promoters. By considering only high-scoring sites we obtained a significant enrichment in TFAP2A-modulated genes compared with total binding sites, as shown by the p-values in the last column (exact Fisher Test).