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Table 3 TFAP2A binding site sequences present in the regulatory regions of some TFAP2A- modulated genes.

From: Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

Gene Symbol ENSEMBL ID Microarray FC TFAP2A binding sequence TFAP2A binding score Position
ESDN/DCBLD2 ENSG00000057019 5.7 GCCGCGGGG 12.74 -269
    GCCCGCAGC 11.54 -10
PPARG ENSG00000132170 2.6 GCCTGAGGC 11.48 -851
    GCCGGGGGC 12.82 -280
    GCCGCGGGG 12.74 -176
    GCCCCGCGG 11.77 -175
    GCCGTGGGC 11.94 -134
    GCCCGGCGC 11.85 +10
    GCCCGCGGC 12.85 +42
EREG ENSG00000124882 2.5 CCCTCGGGC 12.75 -101
CXCL1 ENSG00000163739 2.4 GCCCGGGGG 13.46 -64
    GCCCCCGGG 12.76 -63
    GCCCGGAGC 12.14 -56
    GCCGCAGGC 11.91 +13
CD59 ENSG00000085063 1.7 GCCCTGGGG 12.58 -336
    GCCCCAGGG 12.55 -335
    GCCGGGAGC 11.51 -37
    GCCGGGGGG 12.83 +3
ADAMTS1 ENSG00000154734 1.7 GCCCGCAGC 11.54 -142
    GCCGGGGGC 12.82 -107
SLIT2 ENSG00000145147 1.7 GCCGGGGGC 12.81 -679
    GCCCCGAGG 12.06 -248
CASP9 ENSG00000132906 -1.5 GCCCTGGGG 12.58 -734
    GCCCCCAGG 11.45 -463
    GCCCCCAGG 11.45 -370
    GCCCGCAGG 11.55 -182
    GCCCTGGGG 12.58 +4
    GCCCCCAGG 11.45 +69
    GCCCCGCGC 11.75 +2
TGFBI ENSG00000120708 -1.6 GCCCTGGGG 12.58 -899
    GCCCCCAGC 11.44 -414
    GCCCTGGGC 12.57 -212
    GCCCTGGGC 12.57 +43
GLO1 ENSG00000124767 -2.0 GCCGCGGGC 12.72 -24
FASTK ENSG00000164896 -2.2 GCCCGGAGG 12.15 -856
    GCCCCGAGC 12.04 -500
    GCCCGGGGC 13.45 -413
    GCCCCGGGG 13.36 -393
    GCCCCCGGG 12.76 -391
    GCCCTCGGC 11.97 -66
    GCCCGGCGC 11.85 -59
    GCCCGCGGG 12.86 -42
    GCCGGGAGC 11.51 -2
KRT16 ENSG00000186832 -2.5 GCCCTCGGG 11.98 -860
    GCCCCCGGG 12.76 -650
    GCCTGAGGC 11.48 -502
    GCCCCGAGG 12.06 -279
    GCCCTCGGG 11.98 -277
KRT17 ENSG00000186831 -2.7 GCCCCGGGG 13.36 -525
    GCCCCGGGG 13.36 -524
    GCCCCCAGC 11.44 -203
    GCCTGGGGG 12.30 +56
PLCXD2 ENSG00000144824 -1.5 CCCCCTTGGC 9.47* -878
    GGCCAGGGC 9.04* -64
IFI44 ENSG00000137965 -1.9 - - -
  1. For each ChIP-validated TFAP2A target gene or negative control (see figure 3 and 6) Gene Symbol, ENSEMBL IDs, TFAP2A binding site sequence, score and position (referring to the TSS as +1) are shown. ADAMTS1: ADAM metallopeptidase with thrombospondin type 1 motif, 1; CASP9: caspase 9; CD59: CD59 molecule, complement regulatory protein; CXCL1: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity alpha); DCLBD2/ESDN: Endothelial and smooth muscle cell derived neuropiline like molecule; EREG: Epiregulin; FASTK: fast kinase; GLO1: glyoxalase I; KRT16: keratin 16; KRT17: keratin 17; IFI44: interferon-induced protein 44; PLCXD2: pleckstrin homology-like domain family B member 2; PPARG: peroxisome proliferator activated receptor gamma; SLIT2: slit homolog 2 (Drosophila); TGFBI: Transforming Growth Factor Beta-Induced. * low score binding sites, used as negative controls.