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Table 2 Prednisolone-regulated genes associated with 'gluconeogenesis' in literature.

From: Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Biological process: gluconeogenesis
Gene name Symbol Fc WT Fc GRdim*
Insulin-like growth factor binding protein 1 Igfbp1 9.7 3.6
Tyrosine aminotransferase Tat 4.1 1.6
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Pfkfb3 3.9 2.3
Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Ppargc1a 3.2 3.2
CCAAT/enhancer binding protein (C/EBP), beta Cebpb 3.1 1.6
Protein-tyrosine sulfotransferase 2 Tpst2 2.7 1.5
Solute carrier family 2 (facilitated glucose transporter), member 1 Slc2a1 2.6 1.9
Forkhead box O1 Foxo1 2.2 1.7
Serine dehydratase Sds 2.1 1.5
Aminoadipate-semialdehyde synthase Aass 2.1 1.3
Phosphoenolpyruvate carboxykinase 1, cytosolic Pck1 1.9 1.3
Tryptophan 2,3-dioxygenase Tdo2 1.5 1.2
Aconitase 2, mitochondrial Aco2 1.4 1.3
Transketolase Tkt -1.2 -1.1
Protein kinase, AMP-activated, beta 1 non-catalytic subunit Prkab1 -1.5 1
Adiponectin receptor 2 Adipor2 -1.6 -1.3
Purinergic receptor P2Y, G-protein coupled, 5 P2ry5 -1.6 -1.3
Pyruvate kinase liver and red blood cell Pklr -2.1 -1.4
CCAAT/enhancer binding protein (C/EBP), alpha Cebpa -2.3 -1.2
Sterol regulatory element binding factor 1 Srebf1 -3 -1.6
Insulin receptor substrate 1 Irs1 -4 -1.5
  1. CoPub identified 21 prednisolone-regulated genes in wild type (WT) mice that are associated in literature with gluconeogenesis. The identified genes share at least 3 publications and have an R-scaled score [34] of at least 35 with keyword 'gluconeogenesis' in Medline abstracts. For each gene, the fold change (Fc) in prednisolone versus vehicle-treated WT mice (Fc WT) is given. Additionally, for each gene also the Fc in prednisolone versus vehicle-treated GRdim mice (Fc GRdim) is shown. *It should be noted that in GRdim mice these genes did not meet the p-value cutoff of 0.01 for significance after correction for multiple testing, and are mentioned to illustrate a small effect of prednisolone on gene expression in GRdim mice.