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Table 3 Prednisolone-regulated genes associated with 'cell cycle' in literature.

From: Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Biological process: cell cycle
Gene name Symbol Fc WT Fc GRdim*
Growth arrest and DNA-damage-inducible 45 gamma Gadd45g 17.8 2.9
Dual specificity phosphatase 1 Dusp1 8.2 1
Cyclin-dependent kinase inhibitor 1A (P21) Cdkn1a 8.1 1
Growth arrest and DNA-damage-inducible 45 beta Gadd45b 5.1 1
Polo-like kinase 3 (Drosophila) Plk3 4.5 1
Retinoblastoma binding protein 8 Rbbp8 4.5 1.3
Bcl2-like 1 Bcl2l1 3 1.1
Tensin 1 Tns1 2.6 1.2
Protein tyrosine phosphatase 4a1 Ptp4a1 2.3 1.1
Forkhead box O1 Foxo1 2.2 1.7
PAX interacting (with transcription-activation domain) protein 1 Paxip1 1.9 1
Forkhead box O3a Foxo3a 1.9 -1.1
E1A binding protein p300 Ep300 1.8 1
NIMA (never in mitosis gene a)-related expressed kinase 7 Nek7 1.8 1.1
Cell division cycle 2-like 6 (CDK8-like) Cdc2l6 1.8 1.2
Cell division cycle 40 homolog (yeast) Cdc40 1.4 1
Cyclin D2 Ccnd2 -1.5 -1.2
NIMA (never in mitosis gene a)-related expressed kinase 6 Nek6 -1.7 -1.2
CDC28 protein kinase regulatory subunit 2 Cks2 -2.3 -1.3
TSC22 domain family, member 1 Tsc22d1 -4 -2.3
  1. CoPub identified 65 prednisolone-regulated genes in wild type (WT) mice that are associated in literature with the cell cycle (top 20 shown). The identified genes share at least 3 publications and have an R-scaled score [34] of at least 35 with keyword 'cell cycle' in Medline abstracts. For each gene, the fold change (Fc) in prednisolone versus vehicle-treated WT mice (Fc WT) is given. Additionally, for each gene also the Fc in prednisolone versus vehicle-treated GRdim mice (Fc GRdim) is shown. *It should be noted that in GRdim mice these genes did not meet the p-value cutoff of 0.01 for significance after correction for multiple testing, and are mentioned to illustrate a small effect of prednisolone on gene expression in GRdim mice.