Table 1 Genes associated with the Gene Ontology (GO) biological processes shown in Figure 1B and 1C
From: Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
GO Biological Processes | Associated Genes |
|---|---|
A) Up-regulated GO biological processes | |
Nervous system development (70 genes) | Actr3, Acvr1, Ank3, Apc, Aplp2, Arc, Arhgef2, Arpc2, Atp2b2, Atrx, B3gnt2, Bcl11b, Brsk2, Btg2, Cacna1c, Centb2, Cttn, Diap1, Dpysl2, Egr2, Elavl3, Enah, Epha3, Epha4, Epha6, Epha7, Fos, Fut8, Gja1, Grin2a, Hipk2, Itga8, Kif5c, Klhl24, Lefty1, Mbp, Mef2a, Mib1, Ndel1, Ndst1, Nfib, Nisch, Npnt, Nrcam, Nrp1, Nrp2, Nrxn3, Ntrk2, Ntrk3, Pafah1b1, Pbx1, Pcsk2, Pex2, Prkca, Prkg1, Ptk2, Rsc1a1, Rtn4, Scn2a1, Scn8a, Sema5a, Sh3rf1, Slit3, Tacc1, Top2b, Trpm7, Wasl, Yy1, Zbtb16, Zeb2 |
Intracellular signal transduction (68) | Aak1, Abl2, Acvr1, Add1, Add2, Akt3, Aplp2, Arhgef12, Arhgef2, Atp2b2, Brap, Brsk2, Camk2a, Camk2b, Centb2, Centg2, Csnk1a1, Diap1, Dock10, Dock9, Dyrk1a, Epha3, Epha4, Epha6, Epha7, Fert2, Frap1, Fut8, Hipk2, Hrasls, Itga8, Kalrn, Ksr1, Map2k4, Mapk14, Mapk8, Mtmr1, Mtmr3, Mtmr9, Myo9b, Ndst1, Net1, Nisch, Npnt, Nrp1, Ntrk2, Ntrk3, Pafah1b1, Pftk1, Phip, Phka2, Ppp3ca, Prkca, Prkg1, Ptk2, Ptk2b, Ptprj, Ptprs, Rabgap1, Rps6kb1, Rutbc3, Slc8a2, Slk, Srpk2, Tbc1d15, Tlk2, Trpm7, Uhmk1 |
Cytoskeleton & focal adhesion (38) | Abl2, Actr3, Add1, Add2, Apc, Arc, Arhgef2, Arpc2, Cap2, Capn3, Centb2, Clasp1, Clip1, Coro1c, Diap1, Dmd, Dst, Enah, Enc1, Epb4.1l1, Frmd4b, Gmfb, label, Mtap7, Myo9b, Ndel1, Nisch, Pafah1b1, Polb, Ptk2, Ptk2b, Spire1, Tacc1, Tpm1, Trpm7, Wasf3, Wasl, Wdr1 |
Ion transport & homeostasis (23) | Atp1a1, Atp2b2, Atp2c1, Atp6v0d1, Atp8a1, Atp9b, Cacna1c, Cacna1d, Cacna1h, Cacna2d1, Cacnb2, Camk2a, Camk2b, Grin2a, Grin2b, Ppp3ca, Ryr1, Scn2a1, Scn3b, Scn8a, Slc8a2, Trpc4, Trpm7 |
Synaptic neurotransmission (21) | Arc, Atp2b2, Atxn1, Camk2a, Dlg1, Dlg2, Dlg4, Erc2, Exoc4, Exoc5, Gabbr1, Gabrb2, Gabrb3, Grin2a, Grin2b, Magi2, Nrxn3, Ppp3ca, Rps6kb1, Snca, Vps33a |
mRNA processing (15) | Adar, Cdc40, Cpsf6, Cugbp2, Lsm11, Prpf39, Prpf40a, Sfpq, Sfrs10, Sfrs12, Sfrs8, Srpk2, Srrm2, Syncrip, Tra2a |
Protein mis-folding correction & degradation (9) | Ahsa1, Ahsa2, Dnajc1, Usp12, Usp19, Usp20, Usp32, Usp47, Usp7 |
Cognition & behavior (8) | Atxn1, Cacna1c, Epha4, Grin2a, Grin2b, Itga8, Pafah1b1, Scn8a |
B) Down-regulated GO biological processes | |
Intracellular signal transduction (57) | AW551984, Acvr2b, Adra2a, Angpt1, Anxa1, Arhgap6, Bmper, Cacnb4, Calca, Car8, Cckbr, Cd24a, Cdc42ep1, Cit, D0H4S114, Dcx, Ddit4l, Ddr2, Depdc6, Gnb4, Gng4, Gpr101, Gpr103, Gpr83, Gulp1, Hrh1, Igf1, Khdrbs1, Nr2f2, Pde1c, Pde9a, Pgr, Plcxd3, Plek, Ppard, Ptprd, Rab3b, Reln, Rfxank, Rgs17, Rgs2, Rora, Rspo2, Sh2d3c, Shd, Slc9a3r2, Sparc, Stmn1, Tacr3, Tbc1d8, Tgm2, Timp2, Trhr, Unc13c, Unc5d, Wnt4, Wnt7a |
Gene transcription (33) | 6430502M16Rik, Ankrd56, Arx, Btbd11, Cutl1, Cutl2, Etv6, Foxp2, Hes5, Hivep1, Hoxc6, Ikzf4, Irf6, Khdrbs1, Klf5, Lbh, Ldb2, Lhx2, Maf, Mef2c, Mrg1, Nr2f2, Pbx3, Pgr, Ppard, Prrx1, Rora, Satb1, Satb2, Ssbp2, Trim66, Tshz2, Tshz3 |
Nervous system development (29) | Arx, Atp1a2, Calca, Car10, Cd24a, Cd44, Cit, Cobl, Cutl1, Dcx, Efna5, Foxp2, Gap43, Grin3a, Hes5, Igf1, Lhx2, Nr2f2, Nts, Pex13, Pgr, Ppard, Reln, Rora, Stmn1, Timp2, Tnnt2, Wnt4, Wnt7a |
Cell adhesion & secretion (14) | Amn, Anxa1, Cacnb4, Calca, Cd24a, Cplx3, Cutl1, Exoc6, Ppard, Rab3b, Rims3, Tgm2, Unc13c, Wnt7a |
Synaptic neurotransmission (10) | Atp1a2, Cacnb4, Cckbr, Cplx3, Gpr103, Gpr83, Rims3, Slc17a6, Tacr3, Wnt7a |
Ion homeostasis (4) | Atp1a2, Cacnb4, Calca, Cd24a |