TY - JOUR AU - Noyes, Harry A. AU - Agaba, Morris AU - Anderson, Susan AU - Archibald, Alan L. AU - Brass, Andy AU - Gibson, John AU - Hall, Laurence AU - Hulme, Helen AU - Oh, Sung Jong AU - Kemp, Stephen PY - 2010 DA - 2010/06/07 TI - Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background JO - BMC Genomics SP - 361 VL - 11 IS - 1 AB - Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitive to genetic background. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-11-361 DO - 10.1186/1471-2164-11-361 ID - Noyes2010 ER -