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Figure 5 | BMC Genomics

Figure 5

From: Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

Figure 5

Cholesterol synthesis pathway compiled using GenMapp. Genes regulated by Srebf2 (Srebp2) from Reed et al. [33]. Ratio of Tir1CC to Tir1AA congenic mouse expression is shown on the left of each box and the ratio of C57BL/6 to A/J parental mouse expression is shown on the right of each box. Genes in green boxes have < -0.4 log2 expression ratio in the liver of the congenic mice, genes in yellow have > 0.4 log2 expression ratio in the liver of parental mice. Genes indicated by purple stars are significantly differentially expressed as indicated in the legend. Log2 expression ratios are shown by each gene where the absolute ratio > 0.4 or the ratio is significantly different from 0 as indicated by the stars. Negative log2 ratios indicate higher expression in mice carrying A/J alleles (A/J and Tir1AA) than mice carrying C57BL/6 alleles (C57BL/6 and Tir1CC). None of the genes in this pathway were differentially expressed in Tir3AA v Tir3CC.

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BMC Genomics

ISSN: 1471-2164

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