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Figure 4 | BMC Genomics

Figure 4

From: Insights into shell deposition in the Antarctic bivalve Laternula elliptica: gene discovery in the mantle transcriptome using 454 pyrosequencing

Figure 4

Multiple sequence alignment of the putative PTH/CALR receptor in L. elliptica contig 11573 (Lel_11573) with the N-terminal region of the putative metazoan homologues. The sequence alignment starts from the beginning of the Laternula fragment. Conserved cysteine residues are indicated by dots "•" and the Aspartic acid (D) residue within the N-terminal sequence motif C-x(4)-D-x(3,4)-C-Wx(11,12)-C-P involved in CLR/RAMP/ligand interactions indicates by a cross "+". The beginning of receptor TM1 region is indicated by an arrow and the localisation of putative glycosylation sites (NXT/S) indicated by blue dashed boxes. Amino acid conservation in the alignment is colour coded and black shaded columns mean total residue conservation. Accession numbers of the sequences used in the alignment are: Human (Hsa, PTHR1 NP_000307; CALR NP_001158209; CGRP NP_005786); Chicken (Gga, XP_418507); Zebrafish (Dre, AAI62580); Xenopus laevis (Xla, NP_001080206); Takifugu rubripes (Tru, NP_001098689); Crassostrea virginica (Cvi, JC8022 (est)); Ciona intestinalis (Cin, BAI63096); Crassostrea gigas (Cgi, AM858508); Culex quinquefasciatus (Cqu, XP_001864896); Anopheles gambiae str. PEST (Aga, XP_321982); Ixodes scapularis (Isc, XP_002414039); Apis mellifera (Ame, XP_001122670); Nasonia vitripennis (Nvi, XP_001605780). The predicted invertebrate proteins are marked in italics and were included for comparison with the bivalve (L. Elliptica; Lel) deduced amino acid sequence of contig 11573 which is highlighted in bold.

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