Figure 5

Multiple sequence alignment of the putative PTH/CALR receptor in L. elliptica contig 14182 (Lel_14182) with the TM domain region of putative metazoan homologues. The localization of TM1, TM2 and TM3 are indicated by lines and ICL 1 and 2 (intracellular loop) and ECL1 (extracellular loop) are named. Conserved cysteines are indicated by dots "•" and amino acid residues involved in Gs coupling are marked with a cross "+". Amino acid conservation in the alignment is colour coded and black shaded columns mean total residue conservation. Accession numbers of sequences used in the alignment are the same as for Figure 3 and predicted invertebrate proteins are marked in italics and the deduced amino acid sequence from L. elliptica (Lel) is highlighted in bold.