Figure 1

Consensus clustering define distinct time profiles of gene expression. Consensus clusters of the 3,708 most differentially expressed genes. A. Heatmaps of each consensus cluster illustrating the expression pattern of the genes contained in each cluster. The gene wise expression has been normalized according to eq. 1 resulting in expression between -1 and +1. Color Code: Red signifies up-regulation and green down-regulation compared to the gene-wise average (see color bar). The alternating colored bars below each heatmap illustrate the microarrays of each time point 0, 2, 7, 21 and 60 days post injury. B. The average expression time profile of each consensus cluster, plus/minus one standard deviation. C. Optimal leaf ordered dendrogram showing the Ward distance between each consensus cluster. D. Contour map of the (leaf ordered) co-occurrence matrix. The consensus clusters are indicated along the diagonal with numbers. This figure illustrates the gene overlap between clusters for the consecutive cluster runs with randomized initial settings.