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Table 1 Summary table of QTL comparing results of the F21, F62 and F123 AIL mapping populations.

From: High resolution mapping of trypanosomosis resistance loci Tir 2 and Tir 3 using F12 advanced intercross lines with major locus Tir 1 fixed for the susceptible allele

Tir MMU   F21,7 F6 AIL2, F12 AIL3
Tir 1 17 Map Location (cM) ~14 17.9 cM ND
   CI (cM) ND 0.9 cM ND
   Effect (days) 33.5 38.8 30.0
   PVar (%) 11.8 19.6 ND
Tir2 5 Map Location (cM) ~20 45 41
   CI (cM) ND 12 1
   Effect (days) 22 14.7 8.9
   PVar (%) 5.3 3.3 4.5
Tir 3a 1 Map Location (cM)   59.7 67
   CI (cM)   1.8 6
   Effect (days)   14.45 11.33
   PVar (%)   2.6 6.7
Tir 3b 1 Map Location (cM) 73 73 76
   CI (cM) ND 10 7
   Effect (days) 32 17.3 11.3
   PVar (%) 8.9 4.1 7.9
Tir 3c 1 Map Location (cM)   94 86
   CI (cM)   8 2
   Effect (days)   13.4 12.1
   PVar (%)   2.3 8.6
  1. The most likely map locations (cM) are given as distances in cM from the telomere. Effect, difference between alternative homozygous genotypes (additive effect) in days4; CI, 95% confidence intervals for QTL map location in cM5; PVar, proportion of phenotypic variance explained by each of the Tir loci6.
  2. 1 Data from [7]; Mean of BALB/cJ × C57BL/6J and A/J × C57BL/6J.
  3. 2 Data from [16, 19].
  4. 3 Generated from A/J × C57BL/6J and fixed for MMU17 A/J (susceptible) allele.
  5. 4 For F12 AIL, dominance effects are Tir 2, 4.5; Tir 3a, -1.2; Tir 3b, -5.7; Tir 3c, -5.0.
  6. 5 For F12 AIL, flanking markers defining the most likely interval containing the QTL are: Tir 2, D5MIT258-58; Tir 3a, D1MIT94-140; Tir 3b, D1MIT288-105; Tir 3c, D1MIT107-58.
  7. 6 For F12 AIL, LOD scores are: Tir 2, 3.81; Tir 3a, 4.49; Tir 3b, 3.48; Tir 3c, 3.18.
  8. 7 Tir 3 mapped as a single locus in the F2 experiment.
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BMC Genomics

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