Table 3 The functional annotation categories for the genes regulated by CA IX deficiency.
From: Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach
Functional category | Total regulated genes | Upregulated genes | Downregulated genes |
|---|---|---|---|
Developmental processes* | 20 | 13 | 7 |
Keratinization and keratinocyte differentiation | 8 | 8 | 0 |
Structural molecule activity | 13 | 13 | 0 |
Embryo implantation, female pregnancy, and menstrual cycle | 3 | 3 | 0 |
Rhythmic process | 4 | 3 | 1 |
Multi-organism process | 5 | 5 | 0 |
Cell differentiation | 16 | 12 | 4 |
Serine-type endopeptidase activity, serine hydrolase activity, and serine-type peptidase activity | 9 | 3 | 6 |
Proteolysis | 15 | 6 | 9 |
Peptidase activity | 14 | 5 | 9 |
Endopeptidase activity | 10 | 4 | 6 |
Trypsin and chymotrypsin activity | 4 | 1 | 3 |
Hydrolase activity | 22 | 8 | 14 |
Structural constituent of cytoskeleton | 5 | 5 | 0 |
Cell communication | 4 | 4 | 0 |
Metallocarboxypeptidase activity, carboxypeptidase activity, and metalloexopeptidase activity | 3 | 0 | 3 |
Serine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, and protease inhibitor activity | 4 | 2 | 2 |
Taxis and chemotaxis | 4 | 3 | 1 |
Response to external stimulus | 7 | 4 | 3 |
Immune system process | 10 | 5 | 5 |
Defense response | 7 | 5 | 2 |
Positive regulation of cell differentiation | 3 | 2 | 1 |
PPAR signaling pathway | 3 | 0 | 3 |
Leukocyte migration | 3 | 2 | 1 |