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Table 3 The functional annotation categories for the genes regulated by CA IX deficiency.

From: Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach

Functional category Total regulated genes Upregulated genes Downregulated genes
Developmental processes* 20 13 7
Keratinization and keratinocyte differentiation 8 8 0
Structural molecule activity 13 13 0
Embryo implantation, female pregnancy, and menstrual cycle 3 3 0
Rhythmic process 4 3 1
Multi-organism process 5 5 0
Cell differentiation 16 12 4
Serine-type endopeptidase activity, serine hydrolase activity, and serine-type peptidase activity 9 3 6
Proteolysis 15 6 9
Peptidase activity 14 5 9
Endopeptidase activity 10 4 6
Trypsin and chymotrypsin activity 4 1 3
Hydrolase activity 22 8 14
Structural constituent of cytoskeleton 5 5 0
Cell communication 4 4 0
Metallocarboxypeptidase activity, carboxypeptidase activity, and metalloexopeptidase activity 3 0 3
Serine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, and protease inhibitor activity 4 2 2
Taxis and chemotaxis 4 3 1
Response to external stimulus 7 4 3
Immune system process 10 5 5
Defense response 7 5 2
Positive regulation of cell differentiation 3 2 1
PPAR signaling pathway 3 0 3
Leukocyte migration 3 2 1
  1. *A representative category for the following overlapping categories: epidermis morphogenesis, tissue morphogenesis, epidermis development, ectoderm development, tissue development, organ development, anatomical structure development, anatomical structure morphogenesis, cellular developmental process, multicellular organismal development, and epidermal cell differentiation.