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Table 1 Functional groups of genes identified in the equine skeletal muscle transcriptome.

From: Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training

  

All genes

High abundance genes

GO ID

Term

Count

FC

Adj P

Count

FC

Adj P

GO BP:0008152

metabolic process

2468

1.19

8.17 × 10-55

131

1.2

4.13 × 10-08

GO MF:0005515

protein binding

2122

1.35

4.53 × 10-90

105

1.3

2.88 × 10-12

GO CC:0043234

protein complex

713

1.57

2.75 × 10-43

68

2.9

1.32 × 10-15

GO CC:0005739

mitochondrion

407

1.97

5.63 × 10-49

53

4.9

3.71 × 10-23

GO BP:0006936

muscle contraction

73

1.94

1.78 × 10-07

33

8.7

3.98 × 10-17

hsa00190

Oxidative phosphorylation

56

1.55

0.006

32

9.5

4.47 × 10-18

GO MF:0003723

RNA binding

289

1.76

3.84 × 10-23

27

3.3

3.78 × 10-06

GO MF:0009055

electron carrier activity

94

1.81

1.47 × 10-07

24

9.4

1.43 × 10-11

GO CC:0043292

contractile fibre

50

3.37

3.19 × 10-17

23

29.9

5.32 × 10-18

GO CC:0005840

ribosome

93

1.32

1.63 × 10-02

21

5.8

9.29 × 10-09

GO MF:0005524

ATP binding

434

1.28

1.71 × 10-07

20

1.2

NS

GO BP:0006950

response to stress

337

1.39

9.17 × 10-10

19

1.5

NS

GO CC:0044428

nuclear part

429

1.88

9.51 × 10-46

10

0.8

NS

GO BP:0006457

protein folding

132

2.12

5.64 × 10-18

10

3.1

0.007

GO BP:0015031

protein transport

290

1.85

5.91 × 10-28

7

0.9

NS

GO MF:0045182

translation regulator activity

76

2.40

9.13 × 10-13

5

3.2

NS

GO BP:0006396

RNA processing

195

1.90

8.21 × 10-20

4

0.8

NS

GO MF:0008134

transcription factor binding

153

1.67

1.89 × 10-09

4

0.9

NS

hsa00620

Pyruvate metabolism

27

2.28

3.30 × 10-04

4

3.6

NS

hsa00020

Citrate cycle (TCA cycle)

20

2.36

0.003

4

5.1

NS

hsa04120

Ubiquitin mediated proteolysis

55

1.49

0.016

2

0.6

NS

hsa00071

Fatty acid metabolism

24

1.89

0.017

2

1.7

NS

GO CC:0005681

spliceosome

78

2.71

2.04 × 10-18

1

0.7

NS

hsa03050

Proteasome

21

3.38

2.28 × 10-07

1

1.7

NS

  1. GO categories and KEGG pathways overrepresented among genes expressed in equine skeletal muscle compared to all annotated equine genes. Terms in italics are more significantly overrepresented among the high abundance genes. High abundance genes are defined as those comprising > 0.05% of annotated muscle transcriptome. FC - fold change; Adj P - adjusted P value using the Benjamini and Hochberg method.