Figure 5

Entropies in native and synonymous-codon-shuffled datasets. On the X-axis, the substitution site is labelled as 0, the 5' flank as negative and the 3' flank as positive. The horizontal reference line represents a threshold value. If the observed relative entropy is greater than or equal to the threshold value, its occurrence probability is lower than 0.001 by chance. Means and standard deviations for 1,000 independently synonymous-codon-shuffled samples are indicated by the red circles and blue error bars.