Figure 5
From: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693
Different gene changes support the same processes in cell culture and xenograft experiments. The transcriptomic response to GSK690693 treatment is markedly different in three xenograft models derived from distinct tissues, with only 17 common expression changes (<1% of total). In contrast, a common set of proposed sensitivity mechanisms can explain roughly one-third of the expression changes in each cell line.