Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties

Vitikainen, Marika; Arvas, Mikko; Pakula, Tiina; Oja, Merja; Penttilä, Merja; Saloheimo, Markku

doi:10.1186/1471-2164-11-441

Table 3 List of genes that have a mutation in a promoter, coding region or terminator in strains QM9123 and QM9414.

From: Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties

Strain	Gene ID	Element	AA change	Annotation
Deletions:
QM9123	103044	promoter		Unknown
QM9414	5645	IN		Gamma-glutamyltranspeptidase, plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione and drug and xenobiotic detoxification
QM9123 and QM9414	68956	IN		FAD dependent oxidoreductase, D-amino acid oxidase
Chromosomal breakpoints:
QM9123 and QM9414	76018	IN		CysK Cysteine synthase
QM9123 and QM9414	107460	IN		GTPase activator protein
QM9123 and QM9414	108962	promoter		Unknown, contains a TLDc domain
QM9123 and QM9414	5645	IN
QM9123 and QM9414	68956	IN
Other mutation sites:
QM9123 and QM9414	120127	promoter		Sequence similarity to GATA type zinc finger, asd4, of N. crassa which is involved in ascospore development
QM9123 and QM9414	2439	promoter		ARP2/3 complex protein, candidate arc15, required for the motility and integrity of cortical actin patches
QM9123 and QM9414	57940	terminator		Alternative oxidase, mitochondrial
QM9123 and QM9414	58910	promoter		Unknown
QM9123 and QM9414	108645	promoter		Unknown
QM9123 and QM9414	81136	IN not specified		Hypothetical plasmamembrane proteolipid 3 (induced by high salt or low temp)
QM9123 and QM9414	124022	IN exon	Phe₇₈₄→Tyr	Hypothetical protein
QM9123 and QM9414	70546	promoter		Hypothetical poly(A) polymerase
QM9414	102776	IN not spesified		Unknown
QM9414	104175	IN exon		Unknown, orphan
QM9414	104333	IN exon	Val₄₀₂ →Leu	Ankyrin repeat protein
QM9414	60508	IN intron		UV-endonuclease
QM9414	77661	IN exon	frameshift Pro₁₂₅→	Oxysterol-binding protein
QM9414	62633	IN intron		Unknown
QM9414	122036	promoter		Ribosomal subunit S2/S5
QM9414	78306	promoter		Thiosulphate sulfurtransferase
QM9414	33895	promoter		FKBP peptidylprolyl isomerase
QM9414	108540	terminator		Hypothetical cell wall mannoprotein
QM9414	109278	promoter		Glycoside hydrolase family 24, lysozyme-type
QM9414	109313	promoter		Unknown and 65232
QM9414	65232	promoter		Short-chain dehydrogenase/reductase
QM9414	65021	IN exon		Short-chain dehydrogenase/reductase family
QM9414	65141	IN exon		Cytochrome P450
QM9414	79813	IN intron		Mono-oxygenase, FAD binding
QM9414	23028	IN exon		Hypothetical Ca2+ permeable channel
QM9414	111645	IN exon		Unknown, orphan
QM9414	52499	promoter		Zn-finger protein, C2H2 type
QM9414	124295	promoter		Putative cell wall protein with CFEM domain
QM9123	54781	promoter		Class 1 peptide chain release factor
QM9123	43191	IN exon		Unknown
QM9123	104335	IN not spesified		Unknown
QM9123	35386	IN exon		Hypothetical actin interacting protein 3 (AIP3/BUD6)
QM9123	111849	promoter		xyn4, Glycoside hydrolase family 5

Strain: the strain(s) in which a mutation has been identified, gene id: the gene number according to the protein id in T. reesei database v2.0 [17], gene element: coding region (IN), promoter or terminator. IN exon or IN intron is marked if the site is sequenced or if the probe coordinates allow reliable location of a mutation site in the exon/intron. If the probe coordinates hit near an exon/intron boundary it is marked as IN not specified. AA change: marked if the mutation site has been sequenced and a mutation changes the amino acid sequence; Annotation: description of the protein.

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ISSN: 1471-2164

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