Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species

Table 1 Chlamydiaceae genome features with suspected host and niche specific genes

Species	Genome size (nt)	Protein coding sequences	Tryptophan metabolism	Toxin genes	Plasmid	Bacteriophage	*tyr* P copies	Nucleotide salvaging
C. pneumoniae AR39	1229853	1052	tph	Absent	Absent	Present	Two	guaBA-add, udk, pyrE
C. pneumoniae CWL029	1230230	1073	tph	Absent	Absent	Absent	Two	guaBA-add, udk, pyrE
C. pneumoniae J138	1226565	1072	tph	Absent	Absent	Absent	One	guaBA-add, udk, pyrE
C. pneumoniae TW183	1225935	1113	tph	Absent	Absent	Absent	One	guaBA-add, udk, pyrE
C. pneumoniae LPCoLN	1241024	1095	tph	Absent	Present	Present*	One	udk, pyrE
C. felis Fe/C-56	1166239	1005	trpABFCDR, kynU	Absent	Present	Absent	One	guaBA-add, pyrE
C. caviae GPIC	1173390	1009	trpABFCDR, kynU, prsA, tph	Present	Present	Present	One	guaBA-add, pyrE
C. abortus S26/3	1144377	961	tph	Absent	Absent	Present	One	guaB (pseudogene), pyrE
C. muridarum Nigg	1069412	924	none	Present	Present	Absent	Two	guaBA-add, upp
C. trachomatis serovar D	1042519	894	trpABCR	Present	Present	Absent	Two	None of the above

tph, tryptophan hydroxylase; trp, tryptophan biosynthesis; kynU, kynureninase; prsA, ribose-phosphate pyrophosphokinase; gua, purine biosynthesis; add, adenosine deaminase; udk, uridine kinase; pyrE, UMP synthase; upp, uracil phosphororibosyl transferase. * Asterisk indicates remnants.

ISSN: 1471-2164